High impact information on SUN4

• One protein was related to the PIR protein family, whereas the remaining three (Scw3p, Scw4p, and Scw10p [for soluble cell wall proteins]) were found to be related to glucanases [1].
• Elutriated sun4 delta uth1 delta daughter cells are born larger, and therefore enter S phase sooner than their wild-type counterpart [2].
• Sun4p/Scw3p was recently described as a cell wall protein (Cappellaro et al., 1998) and, consistent with this notion, electron micrographs of sun4 delta cells show defects in the final steps of cell wall septation [2].

Biological context of SUN4

• Our data suggest that Sun4p and Uth1p might contribute to the regulated process of cell wall morphogenesis and septation [2].
• UTH1 (but not SUN4 or SIM1) was also shown to interfere with mitochondria biogenesis [3].

Anatomical context of SUN4

• Sub-localization experiments show that Uth1p is inserted in the outer mitochondrial membrane and that Sun4p is preferentially a matrix protein [4].

References