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Gene Review

HOL1  -  Hol1p

Saccharomyces cerevisiae S288c

Synonyms: N3494, Protein HOL1, YNR055C
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Disease relevance of HOL1

  • HOL1 double mutants and, to a lesser extent, HOL1-1 single mutants show hypersensitivity to specific cations added to the growth medium, including Na+, Li+, Cs+, Be2+, guanidinium ion, and histidinol, but not K+, Rb+, Ca2+, or Mg2+ [1].

High impact information on HOL1


Biological context of HOL1


Associations of HOL1 with chemical compounds

  • Two classes of mutations were obtained: (i) those that altered the coding region of HOL1, conferring the ability to take up histidinol; and (ii) cis-acting mutations (selected in a mutant HOL1-1 background) that increased expression of the Hol1 protein [2].
  • Selection for the ability of Saccharomyces cerevisiae cells to take up histidinol, the biosynthetic precursor to histidine, results in dominant mutations at HOL1 [2].


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