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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CDC60  -  leucine--tRNA ligase CDC60

Saccharomyces cerevisiae S288c

Synonyms: LeuRS, Leucine--tRNA ligase, cytoplasmic, Leucyl-tRNA synthetase, P2564, YPL160W
 
 
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Disease relevance of CDC60

  • However, the anticodon loop of tRNA(Leu), which has no effect on leucylation in E. coli, play a key role for recognition by LeuRS [1].
 

High impact information on CDC60

  • Both SerRS and LeuRS from E.coli were unable to aminoacylate yeast class II tRNAs; in contrast, the yeast counterparts were able to aminoacylate E.coli class II tRNAs [2].
  • Similarity extends to the substrate stringency, exemplified by a cross-species aminoacylation study showing that no class II tRNAs from E. coli or yeast can be leucylated by H. volcanii LeuRS [3].
  • Insertion of an additional nucleotide into the D-loop, which is not involved in the direct interaction with LeuRS, converted tRNA(Ser) to an efficient leucine acceptor [3].
  • Sequence analysis revealed a single open reading frame of 3270 bp and the deduced amino acid sequence showed 50.5% sequence identity to the cytosolic leucyl-tRNA synthetase (LeuRS) from Neurospora crassa, implying that CDC60 encodes the corresponding yeast protein [4].
  • REV3 is located 2.8 centimorgans from CDC60, on chromosome XVI [5].
 

Biological context of CDC60

  • We conclude that there is no alteration in tRNA recognition and aminoacylation by the C. albicans LeuRS, which argues against it having a role in codon reassignment [6].

References

  1. Recognition system of class II tRNA in Escherichia coli and yeast. Soma, A., Himeno, H. Nucleic Acids Symp. Ser. (1997) [Pubmed]
  2. Cross-species aminoacylation of tRNA with a long variable arm between Escherichia coli and Saccharomyces cerevisiae. Soma, A., Himeno, H. Nucleic Acids Res. (1998) [Pubmed]
  3. Unique recognition style of tRNA(Leu) by Haloferax volcanii leucyl-tRNA synthetase. Soma, A., Uchiyama, K., Sakamoto, T., Maeda, M., Himeno, H. J. Mol. Biol. (1999) [Pubmed]
  4. The cell division cycle gene CDC60 encodes cytosolic leucyl-tRNA synthetase in Saccharomyces cerevisiae. Hohmann, S., Thevelein, J.M. Gene (1992) [Pubmed]
  5. REV3, a Saccharomyces cerevisiae gene whose function is required for induced mutagenesis, is predicted to encode a nonessential DNA polymerase. Morrison, A., Christensen, R.B., Alley, J., Beck, A.K., Bernstine, E.G., Lemontt, J.F., Lawrence, C.W. J. Bacteriol. (1989) [Pubmed]
  6. The Candida albicans gene encoding the cytoplasmic leucyl-tRNA synthetase: implications for the evolution of CUG codon reassignment. O'Sullivan, J.M., Mihr, M.J., Santos, M.A., Tuite, M.F. Gene (2001) [Pubmed]
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