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Gene Review

CDC60  -  leucine--tRNA ligase CDC60

Saccharomyces cerevisiae S288c

Synonyms: LeuRS, Leucine--tRNA ligase, cytoplasmic, Leucyl-tRNA synthetase, P2564, YPL160W
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Disease relevance of CDC60

  • However, the anticodon loop of tRNA(Leu), which has no effect on leucylation in E. coli, play a key role for recognition by LeuRS [1].

High impact information on CDC60

  • Both SerRS and LeuRS from E.coli were unable to aminoacylate yeast class II tRNAs; in contrast, the yeast counterparts were able to aminoacylate E.coli class II tRNAs [2].
  • Similarity extends to the substrate stringency, exemplified by a cross-species aminoacylation study showing that no class II tRNAs from E. coli or yeast can be leucylated by H. volcanii LeuRS [3].
  • Insertion of an additional nucleotide into the D-loop, which is not involved in the direct interaction with LeuRS, converted tRNA(Ser) to an efficient leucine acceptor [3].
  • Sequence analysis revealed a single open reading frame of 3270 bp and the deduced amino acid sequence showed 50.5% sequence identity to the cytosolic leucyl-tRNA synthetase (LeuRS) from Neurospora crassa, implying that CDC60 encodes the corresponding yeast protein [4].
  • REV3 is located 2.8 centimorgans from CDC60, on chromosome XVI [5].

Biological context of CDC60

  • We conclude that there is no alteration in tRNA recognition and aminoacylation by the C. albicans LeuRS, which argues against it having a role in codon reassignment [6].


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