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Gene Review

Lars  -  leucyl-tRNA synthetase

Mus musculus

Synonyms: 2310045K21Rik, 3110009L02Rik, AW536573, LeuRS, Leucine--tRNA ligase, cytoplasmic, ...
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High impact information on Lars


Biological context of Lars

  • Since the primary lesion in tsH1 cells is in their leucyl-tRNA synthetase, these results suggest a role for eIF-2 phosphorylation and GEF activity in coupling the rate of polypeptide chain initiation to the activity of the chain elongation machinery [1].

Anatomical context of Lars


Other interactions of Lars

  • Analysis of the size-distribution of partially purified leucyl-tRNA synthetase complexes indicated that, while enzyme preparations from young animals tended to consist of complexes of larger sizes, those from older animals contained smaller complexes, a 10S complex being a major component [4].


  1. Regulation of polypeptide chain initiation in Chinese hamster ovary cells with a temperature-sensitive leucyl-tRNA synthetase. Changes in phosphorylation of initiation factor eIF-2 and in the activity of the guanine nucleotide exchange factor GEF. Clemens, M.J., Galpine, A., Austin, S.A., Panniers, R., Henshaw, E.C., Duncan, R., Hershey, J.W., Pollard, J.W. J. Biol. Chem. (1987) [Pubmed]
  2. Characterization of cell lines showing growth control isolated from both the wild type and a leucyl-tRNA synthetase mutant of Chinese hamster ovary cells. Pollard, J.W., Stanners, C.P. J. Cell. Physiol. (1979) [Pubmed]
  3. Effects of cadmium ions on the initial stage of translation and the cell death in mouse liver. Ivanov, L., Lesauskaite, V., Ivanoviene, L., Sadauskiene, I., Gaileviciūte, R., Karciauskaite, D., Rodovicius, H. Medicina (Kaunas, Lithuania) (2005) [Pubmed]
  4. Age-associated accumulation of heat-labile aminoacyl-tRNA synthetases in mice and rats. Takahashi, R., Goto, S. Archives of gerontology and geriatrics. (1987) [Pubmed]
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