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Gene Review

VPS29  -  Vps29p

Saccharomyces cerevisiae S288c

Synonyms: Carboxypeptidase Y-deficient protein 11, PEP11, VPT6, VTP6, Vacuolar protein sorting-associated protein 29, ...
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High impact information on VPS29

  • The sequences of the VPS29, VPS30, and VPS35 genes do not yet give any clues to the functions of their products [1].
  • We cloned the Arabidopsis thaliana homologs of the three yeast proteins (Vps35, Vps29, and Vps26) constituting the larger subunit of retromer and prepared antisera against them [2].
  • Vps35p recognizes cargo molecules such as Vps10p and interacts strongly with Vps29p [3].
  • The MAG1 gene encodes a homolog of the yeast (Saccharomyces cerevisiae) protein VPS29 [4].
  • VPS29 is a component of a retromer complex for recycling a vacuolar sorting receptor VPS10 from the pre-vacuolar compartment to the Golgi complex [4].

Biological context of VPS29


  1. Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products. Seaman, M.N., Marcusson, E.G., Cereghino, J.L., Emr, S.D. J. Cell Biol. (1997) [Pubmed]
  2. Plant retromer, localized to the prevacuolar compartment and microvesicles in Arabidopsis, may interact with vacuolar sorting receptors. Oliviusson, P., Heinzerling, O., Hillmer, S., Hinz, G., Tse, Y.C., Jiang, L., Robinson, D.G. Plant Cell (2006) [Pubmed]
  3. Vps26p, a component of retromer, directs the interactions of Vps35p in endosome-to-Golgi retrieval. Reddy, J.V., Seaman, M.N. Mol. Biol. Cell (2001) [Pubmed]
  4. AtVPS29, a Putative Component of a Retromer Complex, is Required for the Efficient Sorting of Seed Storage Proteins. Shimada, T., Koumoto, Y., Li, L., Yamazaki, M., Kondo, M., Nishimura, M., Hara-Nishimura, I. Plant Cell Physiol. (2006) [Pubmed]
  5. Human homologues of yeast vacuolar protein sorting 29 and 35. Edgar, A.J., Polak, J.M. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
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