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Gene Review

PEP8  -  retromer subunit PEP8

Saccharomyces cerevisiae S288c

Synonyms: Carboxypeptidase Y-deficient protein 8, GRD6, J1152, VPS26, VPT4, ...
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High impact information on PEP8

  • The gene, PEP8, plays a role in the delivery of proteins to the vacuole [1].
  • Immuno-gold electron microscopy indicated that the Pep8p localized to vacuolar membranes [1].
  • Expression of pep8 in human cells retards their progression through the G1 phase of the cell cycle [2].
  • Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes [3].
  • A bioinformatic analysis of the mouse genome identified an additional transcribed paralog of the Vps26 retromer protein, which we termed Vps26B [4].

Associations of PEP8 with chemical compounds

  • Hydrophobic residues and a glycine in this loop are required for integration into the retromer complex and endosomal localization of human Vps26, and for the function of yeast Vps26 in carboxypeptidase Y sorting [5].

Other interactions of PEP8

  • These results indicate that the vps26(+), vps29(+) and vps35(+) gene products are required for retrograde transport of SpVps10p from the prevacuolar compartment back to the Golgi in Sch. pombe cells [6].


  1. The yeast homolog of H < beta > 58, a mouse gene essential for embryogenesis, performs a role in the delivery of proteins to the vacuole. Bachhawat, A.K., Suhan, J., Jones, E.W. Genes Dev. (1994) [Pubmed]
  2. An artificial cell-cycle inhibitor isolated from a combinatorial library. Cohen, B.A., Colas, P., Brent, R. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  3. Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. Haft, C.R., de la Luz Sierra, M., Bafford, R., Lesniak, M.A., Barr, V.A., Taylor, S.I. Mol. Biol. Cell (2000) [Pubmed]
  4. A novel mammalian retromer component, Vps26B. Kerr, M.C., Bennetts, J.S., Simpson, F., Thomas, E.C., Flegg, C., Gleeson, P.A., Wicking, C., Teasdale, R.D. Traffic (2005) [Pubmed]
  5. The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain. Shi, H., Rojas, R., Bonifacino, J.S., Hurley, J.H. Nat. Struct. Mol. Biol. (2006) [Pubmed]
  6. Vacuolar protein sorting receptor in Schizosaccharomyces pombe. Iwaki, T., Hosomi, A., Tokudomi, S., Kusunoki, Y., Fujita, Y., Giga-Hama, Y., Tanaka, N., Takegawa, K. Microbiology (Reading, Engl.) (2006) [Pubmed]
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