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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MAS2  -  Mas2p

Saccharomyces cerevisiae S288c

Synonyms: Alpha-MPP, MIF2, Mitochondrial-processing peptidase subunit alpha, YHR024C
 
 
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High impact information on MAS2

  • Import of proteins into yeast mitochondria: the purified matrix processing protease contains two subunits which are encoded by the nuclear MAS1 and MAS2 genes [1].
  • Mitochondria from the mif2 mutant were able to import precursor proteins, but not to cleave the presequences [2].
  • RPP showed completely conserved zinc-binding and catalytic residues compared with beta-MPP but barely contained any of the glycine-rich loop region characteristic of alpha-MPP [3].
  • Interestingly, lifetime analysis of tryptophan fluorescence decay of the alpha-MPP subunit revealed about 11% of steady-state fractional intensity due to the long-lived lifetime component, indicating that at least one tryptophan residue is partly buried at the hydrophobic microenvironment [4].
 

Biological context of MAS2

  • The amino-terminal sequences of the two mature subunits were determined; comparison with the deduced amino acid sequences of the corresponding precursors revealed that the MAS1 and MAS2 subunits are synthesized with prepeptides composed of 19 and 13 residues, respectively, which have similar sequences [5].

References

  1. Import of proteins into yeast mitochondria: the purified matrix processing protease contains two subunits which are encoded by the nuclear MAS1 and MAS2 genes. Yang, M., Jensen, R.E., Yaffe, M.P., Oppliger, W., Schatz, G. EMBO J. (1988) [Pubmed]
  2. The processing peptidase of yeast mitochondria: the two co-operating components MPP and PEP are structurally related. Pollock, R.A., Hartl, F.U., Cheng, M.Y., Ostermann, J., Horwich, A., Neupert, W. EMBO J. (1988) [Pubmed]
  3. A protein from a parasitic microorganism, Rickettsia prowazekii, can cleave the signal sequences of proteins targeting mitochondria. Kitada, S., Uchiyama, T., Funatsu, T., Kitada, Y., Ogishima, T., Ito, A. J. Bacteriol. (2007) [Pubmed]
  4. Substrate binding changes conformation of the alpha-, but not the beta-subunit of mitochondrial processing peptidase. Gakh, O., Obsil, T., Adamec, J., Spizek, J., Amler, E., Janata, J., Kalousek, F. Arch. Biochem. Biophys. (2001) [Pubmed]
  5. The MAS-encoded processing protease of yeast mitochondria. Interaction of the purified enzyme with signal peptides and a purified precursor protein. Yang, M.J., Geli, V., Oppliger, W., Suda, K., James, P., Schatz, G. J. Biol. Chem. (1991) [Pubmed]
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