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PMPCA  -  peptidase (mitochondrial processing) alpha

Homo sapiens

Synonyms: Alpha-MPP, INPP5E, KIAA0123, MPPA, Mitochondrial-processing peptidase subunit alpha, ...
 
 
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Disease relevance of PMPCA

  • RT-PCR experiments showed that P55 expresses ENOD12A, but there was little or no increase in the level of its transcript in response to Nod factor or infection with Rhizobium [1].
  • Increased levels of soluble tumour necrosis factor receptor-I (P55) and decreased IgG1 reactivities in HIV-1 patients with cytomegalovirus disease [2].
 

High impact information on PMPCA

  • Molecular docking of the pF1beta presequence peptide to the MPP model suggested binding of the peptide to the negatively charged binding cleft formed by the alpha-MPP and beta-MPP subunits in close proximity to the H111XXE114H115X(116-190)E191 proteolytic active site on beta-MPP [3].
  • The mutants with alanine inserted after Glu70 and Lys215 did not associate with alpha-MPP [4].
  • Despite these variations in mRNA concentration, B. emersonii alpha-MPP protein levels do not change significantly during the life cycle of the fungus, as observed in Western blots [5].
  • Nucleotide sequence analysis revealed that the predicted alpha-MPP polypeptide comprises 474 amino acids with a calculated molecular mass of 51,900 Da, presenting a characteristic mitochondrial signal sequence [5].
  • In an effort to investigate the molecular mechanisms responsible for the drastic morphological changes the mitochondria go through during the life cycle of the aquatic fungus Blastocladiella emersonii, the gene encoding the alpha subunit of the mitochondrial processing peptidase (alpha-MPP) was isolated [5].
 

Biological context of PMPCA

  • The pea mutant line P55 is defective in root nodule formation, and this phenotype is controlled by a single recessive gene [1].
  • IL-6 does not affect DNA synthesis, total cell number, proportion of CD56+ cells, or the expression of IL-2R (both P55 and P75 glycoproteins) in IL-2-cultured thymocytes [6].
 

Anatomical context of PMPCA

  • These results suggest that STPM inhibit lymphocyte proliferation by affecting one or several events occurring in the synthesis and/or expression of IL-2R P55 by a mechanism which is at least partially independent of its inhibitory effect on IL-2 secretion [7].
  • Activation of T lymphocytes also generates a soluble form of this P55 called S-IL-2R [8].
  • P55 was complexed in cell lysates by antiactin antibody and was shown to be a component of the cytoskeleton [9].
  • Comparison with the reports of subdural recording of colour-evoked potentials in the macaque striate cortex suggests that P55 corresponds with the primary excitation via geniculo-cortical fibres and that N87 and P120 represent later stages of cortical processing [10].
 

Associations of PMPCA with chemical compounds

  • We report here the characterization of P55 and P45 by two-dimensional polyacrylamide gel electrophoresis and by peptide mapping of the radioiodinated polypeptides [11].
  • Synaptic junctional complexes (SJCs), isolated by a procedure which preserves presynaptic dense projections (PDPs) contain as their major component a polypeptide (P55) which comigrates with tubulin on sodium dodecyl sulfate - polyacrylamide gels and another major polypeptide (P45) which comigrates with muscle actin [11].
 

Analytical, diagnostic and therapeutic context of PMPCA

  • Furthermore, the interaction of MPP and its subunits with a peptide substrate, as analyzed by surface plasmon resonance, showed that alpha-MPP bound a peptide substrate as efficiently as MPP [4].
  • Additionally, the presence of TNFalpha receptors P55 in terms of protein (identified through cross-linking experiments) and messenger RNA (identified through RT-PCR analysis) suggested that the effects of the cytokine are directly exerted on the testicular steroidogenic cell type [12].
  • Northern blot analysis indicated a single 1.4-kb transcript encoding the B. emersonii alpha-MPP, whose levels decrease during sporulation, becoming very low in the zoospore, and increase again during germination [5].

References

  1. Genetic mapping and functional analysis of a nodulation-defective mutant (sym19) of pea (Pisum sativum L.). Schneider, A., Walker, S.A., Poyser, S., Sagan, M., Ellis, T.H., Downie, J.A. Mol. Gen. Genet. (1999) [Pubmed]
  2. Increased levels of soluble tumour necrosis factor receptor-I (P55) and decreased IgG1 reactivities in HIV-1 patients with cytomegalovirus disease. Jakobsen, P.H., Dodt, K.K., Meyer, C.N., Katzenstein, T., Gerstoft, J., Skinhøj, P. Scand. J. Immunol. (1998) [Pubmed]
  3. Mutagenesis and computer modelling approach to study determinants for recognition of signal peptides by the mitochondrial processing peptidase. Zhang, X.P., Sjöling, S., Tanudji, M., Somogyi, L., Andreu, D., Eriksson, L.E., Gräslund, A., Whelan, J., Glaser, E. Plant J. (2001) [Pubmed]
  4. Functional cooperation of the mitochondrial processing peptidase subunits. Luciano, P., Geoffroy, S., Brandt, A., Hernandez, J.F., Géli, V. J. Mol. Biol. (1997) [Pubmed]
  5. Characterization and submitochondrial localization of the alpha subunit of the mitochondrial processing peptidase from the aquatic fungus Blastocladiella emersonii. Rocha, C.R., Gomes, S.L. J. Bacteriol. (1999) [Pubmed]
  6. IL-6 enhances the cytotoxic activity of thymocyte-derived CD56+ cells. Iho, S., Shau, H., Golub, S.H. Cell. Immunol. (1992) [Pubmed]
  7. The inhibitory effect of human syncytiotrophoblast plasma membrane vesicles on in vitro lymphocyte proliferation is associated with reduced interleukin 2 receptor expression. Thibault, G., Degenne, D., Girard, A.C., Guillaumin, J.M., Lacord, M., Bardos, P. Cell. Immunol. (1991) [Pubmed]
  8. Soluble interleukin 2 receptor (Tac chain) is not a reliable marker in kidney transplant recipient monitoring. Trochu, J.N., Denis, M., Auget, J.L., Giral, M., Jacques, Y., Soulillou, J.P., Le Mauff, B. Transpl. Int. (1992) [Pubmed]
  9. Membrane-mediated responses to 12-O-tetradecanoylphorbol-13-acetate in human skin fibroblasts. Kinsella, A.R., Whetton, A.D., De Wynter, E., Bazill, G.W., Heyworth, C.M., Houslay, M.D. IARC Sci. Publ. (1984) [Pubmed]
  10. Colour and brightness components of foveal visual evoked potentials in man. Paulus, W.M., Hömberg, V., Cunningham, K., Halliday, A.M., Rohde, N. Electroencephalography and clinical neurophysiology. (1984) [Pubmed]
  11. Actin-like and tubulin-like proteins in synaptic junctional complexes. Mushynski, W.E., Glen, S., Thérien, H.M. Can. J. Biochem. (1978) [Pubmed]
  12. Tumor necrosis factor-alpha inhibits leydig cell steroidogenesis through a decrease in steroidogenic acute regulatory protein expression. Mauduit, C., Gasnier, F., Rey, C., Chauvin, M.A., Stocco, D.M., Louisot, P., Benahmed, M. Endocrinology (1998) [Pubmed]
 
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