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Gene Review

NVJ1  -  Nvj1p

Saccharomyces cerevisiae S288c

Synonyms: Nucleus-vacuole junction protein 1, VAB36, YHR195W
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High impact information on NVJ1

  • These results indicate that Nvj1p retains and compartmentalizes Tsc13p at NV junctions and that VLCFAs contribute to the normal biogenesis of trilaminar PMN structures in yeast [1].
  • The targeting of Tsc13p-GFP into NV junctions is perturbed by cerulenin, suggesting that its binding to Nvj1p depends on the availability of fatty acid substrates [1].
  • Nucleus-vacuole (NV) junctions in Saccharomyces cerevisiae are formed through specific interactions between Vac8p on the vacuole membrane and Nvj1p in the nuclear envelope [2].
  • Nvj1p green fluorescent protein (GFP) concentrated in small patches or rafts at sites of close contact between the nucleus and one or more vacuoles [3].
  • Nvj1p is an integral membrane protein of the nuclear envelope and interacts with Vac8p in the cytosol through its C-terminal 40-60 amino acids (aa) [3].

Biological context of NVJ1

  • In response to nutrient depletion, Nvj1p increasingly binds and sequesters two proteins with roles in lipid metabolism, Osh1p and Tsc13p [4].

Anatomical context of NVJ1


Co-localisations of NVJ1

  • Orphan rafts of Vac8p red-sifted GFP (YFP) colocalize at sites of NV junctions with Nvj1p blue-sifted GFP (CFP) [3].

Other interactions of NVJ1

  • Osh1p is targeted to NV junctions proportional to NVJ1 expression through a physical association with Nvj1p [5].
  • Here we describe the surprising role of Vac8p-Nvj1p complexes in the formation of nucleus-vacuole (NV) junctions [3].


  1. Targeting of Tsc13p to nucleus-vacuole junctions: a role for very-long-chain fatty acids in the biogenesis of microautophagic vesicles. Kvam, E., Gable, K., Dunn, T.M., Goldfarb, D.S. Mol. Biol. Cell (2005) [Pubmed]
  2. Piecemeal microautophagy of nucleus in Saccharomyces cerevisiae. Roberts, P., Moshitch-Moshkovitz, S., Kvam, E., O'Toole, E., Winey, M., Goldfarb, D.S. Mol. Biol. Cell (2003) [Pubmed]
  3. Nucleus-vacuole junctions in Saccharomyces cerevisiae are formed through the direct interaction of Vac8p with Nvj1p. Pan, X., Roberts, P., Chen, Y., Kvam, E., Shulga, N., Huang, K., Lemmon, S., Goldfarb, D.S. Mol. Biol. Cell (2000) [Pubmed]
  4. Nucleus-vacuole junctions and piecemeal microautophagy of the nucleus in s. Cerevisiae. Kvam, E., Goldfarb, D.S. Autophagy (2007) [Pubmed]
  5. Nvj1p is the outer-nuclear-membrane receptor for oxysterol-binding protein homolog Osh1p in Saccharomyces cerevisiae. Kvam, E., Goldfarb, D.S. J. Cell. Sci. (2004) [Pubmed]
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