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Gene Review:

SER3 - phosphoglycerate dehydrogenase SER3

Saccharomyces cerevisiae S288c

Synonyms: 3-PGDH 1, D-3-phosphoglycerate dehydrogenase 1, YER081W

Martens, J.A. et al., Albers, E. et al., Martens, J.A. et al., Duina, A.A. et al.

Albers, Laizé, Blomberg, Hohmann, Gustafsson,

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High impact information on SER3

We now show that SRG1 transcription is regulated by serine, thereby conferring regulation of SER3, a serine biosynthetic gene [1].
However, in striking contrast to activation by Swi/Snf, which requires most Swi/Snf subunits, repression by Swi/Snf at SER3 is dependent primarily on one Swi/Snf component, Snf2 [2].
Furthermore, we show that Swi/Snf occupancy at two promoters, PHO84 and SER3, is reduced in hht2-11 mutants [3].
Moreover, since phosphoglycerate dehydrogenase activity requires NAD(+) as cofactor, deletion of SER3 and SER33 markedly affected redox metabolism as shown by substrate and product analysis [4].

Analytical, diagnostic and therapeutic context of SER3

We now present chromatin immunoprecipitation evidence that the Swi/Snf complex of Saccharomyces cerevisiae directly represses transcription of the SER3 gene [2].

References

Regulation of an intergenic transcript controls adjacent gene transcription in Saccharomyces cerevisiae. Martens, J.A., Wu, P.Y., Winston, F. Genes Dev. (2005) [Pubmed]
Evidence that Swi/Snf directly represses transcription in S. cerevisiae. Martens, J.A., Winston, F. Genes Dev. (2002) [Pubmed]
Analysis of a mutant histone H3 that perturbs the association of Swi/Snf with chromatin. Duina, A.A., Winston, F. Mol. Cell. Biol. (2004) [Pubmed]
Ser3p (Yer081wp) and Ser33p (Yil074cp) are phosphoglycerate dehydrogenases in Saccharomyces cerevisiae. Albers, E., Laizé, V., Blomberg, A., Hohmann, S., Gustafsson, L. J. Biol. Chem. (2003) [Pubmed]

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AGOS_ACL032C	Ashbya gossypii ATCC 10895
KLLA0C09306g	Kluyveromyces lactis NRRL Y-1140
MGG_11794	Magnaporthe oryzae 70-15
NCU01439	Neurospora crassa OR74A
SER33	Saccharomyces cerevisiae S288c
SPCC364.07	Schizosaccharomyces pombe 972h-

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