The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SER3  -  phosphoglycerate dehydrogenase SER3

Saccharomyces cerevisiae S288c

Synonyms: 3-PGDH 1, D-3-phosphoglycerate dehydrogenase 1, YER081W
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on SER3

  • We now show that SRG1 transcription is regulated by serine, thereby conferring regulation of SER3, a serine biosynthetic gene [1].
  • However, in striking contrast to activation by Swi/Snf, which requires most Swi/Snf subunits, repression by Swi/Snf at SER3 is dependent primarily on one Swi/Snf component, Snf2 [2].
  • Furthermore, we show that Swi/Snf occupancy at two promoters, PHO84 and SER3, is reduced in hht2-11 mutants [3].
  • Moreover, since phosphoglycerate dehydrogenase activity requires NAD(+) as cofactor, deletion of SER3 and SER33 markedly affected redox metabolism as shown by substrate and product analysis [4].

Analytical, diagnostic and therapeutic context of SER3


  1. Regulation of an intergenic transcript controls adjacent gene transcription in Saccharomyces cerevisiae. Martens, J.A., Wu, P.Y., Winston, F. Genes Dev. (2005) [Pubmed]
  2. Evidence that Swi/Snf directly represses transcription in S. cerevisiae. Martens, J.A., Winston, F. Genes Dev. (2002) [Pubmed]
  3. Analysis of a mutant histone H3 that perturbs the association of Swi/Snf with chromatin. Duina, A.A., Winston, F. Mol. Cell. Biol. (2004) [Pubmed]
  4. Ser3p (Yer081wp) and Ser33p (Yil074cp) are phosphoglycerate dehydrogenases in Saccharomyces cerevisiae. Albers, E., Laizé, V., Blomberg, A., Hohmann, S., Gustafsson, L. J. Biol. Chem. (2003) [Pubmed]
WikiGenes - Universities