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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

KRT38  -  keratin 38, type I

Homo sapiens

Synonyms: HA8, HHA8, HKA8, Hair keratin, type I Ha8, K38, ...
 
 
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Disease relevance of KRT38

  • It was demonstrated that an engineered HAS2 expressed in E. coli exhibited significant activity to synthesize a mixture of HAS oligomers from 8-mer (HA8) to 16-mer (HA16) [1].
  • Neutralizing titers against measles virus (MV) and human adenovirus 8 (HA8) were also tested [2].
 

High impact information on KRT38

  • The expression of hHa8 in only single cortex cells of the hair follicle was also preserved in cells of the keratogenous zone [3].
  • As a test case, we used a CTL clone that recognizes HA-8, a minor histocompatibility antigen encoded by the KIAA0020 gene and presented by HLA-A*0201 [4].
  • Analysis of 9p marker haplotypes for individuals in the three families identified several individuals with recombinant haplotypes, and these recombination events were used to refine the precision of the HA-8 gene localization further [4].
  • Pairwise linkage analysis of the segregation of HA-8 expression in these pedigrees demonstrated that the HA-8 gene was tightly linked with a cluster of marker loci located on the distal portion of chromosome 9p [4].
  • However, two isolates (HN1 and HA8) showed a strong inhibition of myeloma cell proliferation (16.7 and 5.0%, respectively) by MTT assay [5].

References

  1. An engineered hyaluronan synthase: characterization for recombinant human hyaluronan synthase 2 Escherichia coli. Hoshi, H., Nakagawa, H., Nishiguchi, S., Iwata, K., Niikura, K., Monde, K., Nishimura, S. J. Biol. Chem. (2004) [Pubmed]
  2. Canine viruses and multiple sclerosis. Appel, M.J., Glickman, L.T., Raine, C.S., Tourtellotte, W.W. Neurology (1981) [Pubmed]
  3. Expression of hair keratins in the adult nail unit: an immunohistochemical analysis of the onychogenesis in the proximal nail fold, matrix and nail bed. Perrin, C., Langbein, L., Schweizer, J. Br. J. Dermatol. (2004) [Pubmed]
  4. Feasibility of using genetic linkage analysis to identify the genes encoding T cell-defined minor histocompatibility antigens. Warren, E.H., Otterud, B.E., Linterman, R.W., Brickner, A.G., Engelhard, V.H., Leppert, M.F., Martin, P.J., Riddell, S.R. Tissue Antigens (2002) [Pubmed]
  5. Anti-proliferative effect of two lactic acid bacteria strains of human origin on the growth of a myeloma cell line. Zabala, A., Martín, M.R., Haza, A.I., Fernández, L., Rodríguez, J.M., Morales, P. Lett. Appl. Microbiol. (2001) [Pubmed]
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