Gene Review:
HAS2 - hyaluronan synthase 2
Homo sapiens
Synonyms:
HA synthase 2, Hyaluronan synthase 2, Hyaluronate synthase 2, Hyaluronic acid synthase 2
Spicer,
Seldin,
Olsen,
Brown,
Wells,
Doggett,
Itano,
Kimata,
Inazawa,
McDonald,
Stuhlmeier,
Pollaschek,
Recklies,
White,
Melching,
Roughley,
Yabushita,
Noguchi,
Kishida,
Fusano,
Noguchi,
Itano,
Kimata,
Noguchi,
Paiva,
Van Damme,
Tellbach,
Jones,
Jobling,
Salamonsen,
Oguchi,
Ishiguro,
Simpson,
Stuhlmeier,
- Differential regulation and expression of hyaluronan synthases in human articular chondrocytes, synovial cells and osteosarcoma cells. Recklies, A.D., White, C., Melching, L., Roughley, P.J. Biochem. J. (2001)
- Chromosomal localization of the human and mouse hyaluronan synthase genes. Spicer, A.P., Seldin, M.F., Olsen, A.S., Brown, N., Wells, D.E., Doggett, N.A., Itano, N., Kimata, K., Inazawa, J., McDonald, J.A. Genomics (1997)
- Hyaluronan synthase expression in ovarian cancer. Yabushita, H., Noguchi, M., Kishida, T., Fusano, K., Noguchi, Y., Itano, N., Kimata, K., Noguchi, M. Oncol. Rep. (2004)
- Differential stimulation of three forms of hyaluronan synthase by TGF-beta, IL-1beta, and TNF-alpha. Oguchi, T., Ishiguro, N. Connect. Tissue Res. (2004)
- Concurrent expression of hyaluronan biosynthetic and processing enzymes promotes growth and vascularization of prostate tumors in mice. Simpson, M.A. Am. J. Pathol. (2006)
- Characterization of hyaluronan synthase expression and hyaluronan synthesis in bone marrow mesenchymal progenitor cells: predominant expression of HAS1 mRNA and up-regulated hyaluronan synthesis in bone marrow cells derived from multiple myeloma patients. Calabro, A., Oken, M.M., Hascall, V.C., Masellis, A.M. Blood (2002)
- Antisense-mediated suppression of hyaluronan synthase 2 inhibits the tumorigenesis and progression of breast cancer. Udabage, L., Brownlee, G.R., Waltham, M., Blick, T., Walker, E.C., Heldin, P., Nilsson, S.K., Thompson, E.W., Brown, T.J. Cancer Res. (2005)
- Identification and analysis of the promoter region of the human hyaluronan synthase 2 gene. Monslow, J., Williams, J.D., Guy, C.A., Price, I.K., Craig, K.J., Williams, H.J., Williams, N.M., Martin, J., Coleman, S.L., Topley, N., Spicer, A.P., Buckland, P.R., Davies, M., Bowen, T. J. Biol. Chem. (2004)
- Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells. Simpson, M.A., Wilson, C.M., Furcht, L.T., Spicer, A.P., Oegema, T.R., McCarthy, J.B. J. Biol. Chem. (2002)
- Natural antisense mRNAs to hyaluronan synthase 2 inhibit hyaluronan biosynthesis and cell proliferation. Chao, H., Spicer, A.P. J. Biol. Chem. (2005)
- Cyclic mechanical stretch augments hyaluronan production in cultured human uterine cervical fibroblast cells. Takemura, M., Itoh, H., Sagawa, N., Yura, S., Korita, D., Kakui, K., Kawamura, M., Hirota, N., Maeda, H., Fujii, S. Mol. Hum. Reprod. (2005)
- Expression of hyaluronan synthase in intraocular proliferative diseases: regulation of expression in human vascular endothelial cells by transforming growth factor-beta. Suzuki, K., Yamamoto, T., Usui, T., Suzuki, K., Heldin, P., Yamashita, H. Jpn. J. Ophthalmol. (2003)
- Expression of human hyaluronan synthases in response to external stimuli. Jacobson, A., Brinck, J., Briskin, M.J., Spicer, A.P., Heldin, P. Biochem. J. (2000)
- Effects of leflunomide on hyaluronan synthases (HAS): NF-kappa B-independent suppression of IL-1-induced HAS1 transcription by leflunomide. Stuhlmeier, K.M. J. Immunol. (2005)
- Glucocorticoids inhibit induced and non-induced mRNA accumulation of genes encoding hyaluronan synthases (HAS): hydrocortisone inhibits HAS1 activation by blocking the p38 mitogen-activated protein kinase signalling pathway. Stuhlmeier, K.M., Pollaschek, C. Rheumatology (Oxford, England) (2004)
- Antisense inhibition of hyaluronan synthase-2 in human articular chondrocytes inhibits proteoglycan retention and matrix assembly. Nishida, Y., Knudson, C.B., Nietfeld, J.J., Margulis, A., Knudson, W. J. Biol. Chem. (1999)
- Glucocorticoids induce a near-total suppression of hyaluronan synthase mRNA in dermal fibroblasts and in osteoblasts: a molecular mechanism contributing to organ atrophy. Zhang, W., Watson, C.E., Liu, C., Williams, K.J., Werth, V.P. Biochem. J. (2000)
- Regulation of renal proximal tubular epithelial cell hyaluronan generation: implications for diabetic nephropathy. Jones, S., Jones, S., Phillips, A.O. Kidney Int. (2001)
- The effect of mechanical strain on hyaluronan metabolism in embryonic fibrocartilage cells. Dowthwaite, G.P., Ward, A.C., Flannely, J., Suswillo, R.F., Flannery, C.R., Archer, C.W., Pitsillides, A.A. Matrix Biol. (1999)
- Enamel matrix derivative induces matrix synthesis by cultured human periodontal fibroblast cells. Haase, H.R., Bartold, P.M. J. Periodontol. (2001)
- Induction of hyaluronic acid synthase 2 (HAS2) in human vascular smooth muscle cells by vasodilatory prostaglandins. Sussmann, M., Sarbia, M., Meyer-Kirchrath, J., Nüsing, R.M., Schrör, K., Fischer, J.W. Circ. Res. (2004)
- Stimulation of hyaluronan metabolism by interleukin-1alpha in human articular cartilage. Nishida, Y., D'Souza, A.L., Thonar, E.J., Knudson, W. Arthritis Rheum. (2000)
- The over-expression of HAS2, Hyal-2 and CD44 is implicated in the invasiveness of breast cancer. Udabage, L., Brownlee, G.R., Nilsson, S.K., Brown, T.J. Exp. Cell Res. (2005)
- Differential regulation of hyaluronic acid synthase isoforms in human saphenous vein smooth muscle cells: possible implications for vein graft stenosis. van den Boom, M., Sarbia, M., von Wnuck Lipinski, K., Mann, P., Meyer-Kirchrath, J., Rauch, B.H., Grabitz, K., Levkau, B., Schrör, K., Fischer, J.W. Circ. Res. (2006)
- Nucleus pulposus notochord cells secrete connective tissue growth factor and Up-regulate proteoglycan expression by intervertebral disc chondrocytes. Erwin, W.M., Ashman, K., O'donnel, P., Inman, R.D. Arthritis Rheum. (2006)
- Hyaluronan synthase 3 regulates hyaluronan synthesis in cultured human keratinocytes. Sayo, T., Sugiyama, Y., Takahashi, Y., Ozawa, N., Sakai, S., Ishikawa, O., Tamura, M., Inoue, S. J. Invest. Dermatol. (2002)
- Towards profiling the gene expression of fibroblasts from atopic dermatitis patients: human 8K complementary DNA microarray. Park, Y.D., Lyou, Y.J., Lee, K.J., Lee, D.Y., Yang, J.M. Clin. Exp. Allergy (2006)
- Expression patterns of hyaluronan, hyaluronan synthases and hyaluronidases indicate a role for hyaluronan in the progression of endometrial cancer. Paiva, P., Van Damme, M.P., Tellbach, M., Jones, R.L., Jobling, T., Salamonsen, L.A. Gynecol. Oncol. (2005)