The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

ipgC  -  invasion plasmid antigen

Shigella flexneri 5a str. M90T

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ipgC


High impact information on ipgC

  • Invasion plasmid antigen C (IpaC) has been identified as the primary effector protein for Shigella invasion of epithelial cells [3].
  • Nucleotide sequence of invasion plasmid antigen gene ipaA from Shigella flexneri 5 [4].
  • Plasmids expressing His6-IpgC either alone or together with IpaB or IpaC under the control of an IPTG-inducible lac promoter were introduced into ipgC, ipaB or ipaC mutants [5].
  • The first region was cloned into an E. coli HB101 strain containing noninvasive Tn1 insertion mutants of the form I plasmid, and expression of ipa (invasion plasmid antigen) gene products was restored [6].
  • Recombinant plasmids carrying this regulatory gene, designated ipaR, were found to restore full virulence to a non-invasive ipaR::Tn5 insertion mutant [M90T-W(pHS1042)] that had lost the ability to synthesize four Ipa antigens (IpaA, 70 kDa; IpaB, 62 kDa; IpaC, 42 kDa; and IpaD, 37 kDa) [7].

Chemical compound and disease context of ipgC


Biological context of ipgC


Analytical, diagnostic and therapeutic context of ipgC


  1. Characterization of invasion plasmid antigen genes (ipaBCD) from Shigella flexneri. Venkatesan, M.M., Buysse, J.M., Kopecko, D.J. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  2. Detection of virulent Shigella and enteroinvasive Escherichia coli by induction of the 43 kDa invasion plasmid antigen, ipaC. Shamlal, R., Rajarathnam, S., Sankaran, K., Ramachandran, V., Subrahmanyam, Y.V., Nair, G.B., Macaden, R., Roy, R.K. FEMS Immunol. Med. Microbiol. (1997) [Pubmed]
  3. Structure-function analysis of invasion plasmid antigen C (IpaC) from Shigella flexneri. Kueltzo, L.A., Osiecki, J., Barker, J., Picking, W.L., Ersoy, B., Picking, W.D., Middaugh, C.R. J. Biol. Chem. (2003) [Pubmed]
  4. Nucleotide sequence of invasion plasmid antigen gene ipaA from Shigella flexneri 5. Venkatesan, M.M., Buysse, J.M. Nucleic Acids Res. (1990) [Pubmed]
  5. The secreted IpaB and IpaC invasins and their cytoplasmic chaperone IpgC are required for intercellular dissemination of Shigella flexneri. Page, A.L., Ohayon, H., Sansonetti, P.J., Parsot, C. Cell. Microbiol. (1999) [Pubmed]
  6. Cloning of regions required for contact hemolysis and entry into LLC-MK2 cells from Shigella sonnei form I plasmid: virF is a positive regulator gene for these phenotypes. Kato, J., Ito, K., Nakamura, A., Watanabe, H. Infect. Immun. (1989) [Pubmed]
  7. Molecular characterization of a trans-acting, positive effector (ipaR) of invasion plasmid antigen synthesis in Shigella flexneri serotype 5. Buysse, J.M., Venkatesan, M., Mills, J.A., Oaks, E.V. Microb. Pathog. (1990) [Pubmed]
  8. Identification of RanBMP interacting with Shigella flexneri IpaC invasin by two-hybrid system of yeast. Yao, X., Wang, H.L., Shi, Z.X., Yan, X.Y., Feng, E.L., Yang, B.L., Huang, L.Y. World J. Gastroenterol. (2003) [Pubmed]
  9. Antibody response of monkeys to invasion plasmid antigen D after infection with Shigella spp. Oaks, E.V., Picking, W.D., Picking, W.L. Clin. Diagn. Lab. Immunol. (1996) [Pubmed]
  10. Molecular cloning of invasion plasmid antigen (ipa) genes from Shigella flexneri: analysis of ipa gene products and genetic mapping. Buysse, J.M., Stover, C.K., Oaks, E.V., Venkatesan, M., Kopecko, D.J. J. Bacteriol. (1987) [Pubmed]
WikiGenes - Universities