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Gene Review

pchP  -  phosphorylcholine phosphatase

Pseudomonas aeruginosa PAO1

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Disease relevance of pchP


High impact information on pchP

  • Both recombinant enzymes exhibited a molecular mass of approximately 40 kDa, as expected for the size of the PA5292 gene, and catalyzed the hydrolysis of phosphorylcholine, phosphorylethanolamine, and p-nitrophenylphosphate [2].
  • Molecular analysis of the P. aeruginosa mutant JUF8-00, after Tn5-751 mutagenesis, revealed that the PA5292 gene in the P. aeruginosa PAO1 genome was responsible for the synthesis of PChP [2].


  1. Critical Active-Site Residues Identified by Site-Directed Mutagenesis in Pseudomonas aeruginosa Phosphorylcholine Phosphatase, A New Member of the Haloacid Dehalogenases Hydrolase Superfamily. Beassoni, P.R., Otero, L.H., Massimelli, M.J., Lisa, A.T., Domenech, C.E. Curr. Microbiol. (2006) [Pubmed]
  2. Identification, cloning, and expression of Pseudomonas aeruginosa phosphorylcholine phosphatase gene. Massimelli, M.J., Beassoni, P.R., Forrellad, M.A., Barra, J.L., Garrido, M.N., Domenech, C.E., Lisa, A.T. Curr. Microbiol. (2005) [Pubmed]
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