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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

fptA  -  Fe(III)-pyochelin outer membrane receptor

Pseudomonas aeruginosa PAO1

 
 
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Disease relevance of fptA

  • PchR, a regulator of ferripyochelin receptor gene (fptA) expression in Pseudomonas aeruginosa, functions both as an activator and as a repressor [1].
  • The promoter of the fptA gene contained the sequence 5'-ATAATGATAAGCATTATC-3', which matches the consensus E. coli Fur-binding site at 17 of 18 positions [2].
 

High impact information on fptA

  • One of them is a well-characterized virulence gene (fptA), encoding the receptor for pyochelin, which is a P. aeruginosa iron siderophore [3].
  • As was expected, the expression of fptA decreased dramatically following the inactivation of pchR by the insertion of an OmegaHg cartridge, although the effect (> 10-fold) was not as dramatic as that of pyochelin deficiency, which obviated fptA gene expression [1].
  • The involvement of FptA in this control is unclear, although it may be important in mediating the pyochelin effect on fptA expression, possibly by modulating PchR activity [1].
  • Two related heptameric sequences, CGAGGAA and CGTGGAT, were identified upstream of the putative -35 region of both fptA and pchR and may function as a binding site for PchR [1].
  • The N-terminal amino acid sequence of the isolated FptA protein corresponded to that deduced from the nucleotide sequence of the fptA structural gene [2].
 

Biological context of fptA

  • The -10 promoter region and transcriptional start site of the fptA gene reside within this Fur-binding site [2].
 

Associations of fptA with chemical compounds

  • The fptA gene was strongly regulated by iron; fptA transcription was totally repressed by 30 microM FeCl3, as determined by Northern (RNA) blotting [2].
 

Other interactions of fptA

  • The fptA mutant did not, however, exhibit a defect in pchR expression [1].

References

 
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