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Gene Review

fliD  -  flagellar capping protein FliD

Pseudomonas aeruginosa PAO1

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Disease relevance of fliD

  • The results of PCR and nucleotide sequencing of the fliD region of eight different P. aeruginosa strains (laboratory strains PAK, PAO1, and PA103; clinical strains 1244, CS2, and CS32; cystic fibrosis strains CS29 and MDR) suggested that there were two distinct types of FliD in P. aeruginosa, which we named A type and B type [1].
  • Binding of Pseudomonas aeruginosa strain PAK to mucin has been shown to be mediated by the flagellar cap protein, product of the fliD gene [1].

High impact information on fliD

  • Similar Western blot analyses of 50 more P. aeruginosa strains obtained from varied sources revealed that all strains contained either A-type or B-type FliD, suggesting the existence of only two types of FliD in P. aeruginosa and indicating that fliC and fliD were coinherited [1].
  • The results of the beta-galactosidase assays suggest that the fliD gene in P. aeruginosa is regulated by the newly described transcriptional regulator FleQ and the alternate sigma factor sigma54 (RpoN) [2].
  • The adhesive phenotype was restored by providing the fliD gene alone on a multicopy plasmid, suggesting involvement of this gene in mucin adhesion of P. aeruginosa [2].
  • Consistent with this finding, no sigma28 binding sequence could be identified in the fliD promoter region [2].


  1. Identification of two distinct types of flagellar cap proteins, FliD, in Pseudomonas aeruginosa. Arora, S.K., Dasgupta, N., Lory, S., Ramphal, R. Infect. Immun. (2000) [Pubmed]
  2. The Pseudomonas aeruginosa flagellar cap protein, FliD, is responsible for mucin adhesion. Arora, S.K., Ritchings, B.W., Almira, E.C., Lory, S., Ramphal, R. Infect. Immun. (1998) [Pubmed]
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