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Gene Review

fleQ  -  transcriptional regulator FleQ

Pseudomonas aeruginosa PAO1

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Disease relevance of fleQ

  • The alternative sigma factor AlgT represses Pseudomonas aeruginosa flagellum biosynthesis by inhibiting expression of fleQ [1].
  • Thus, our data show that AlgT inhibits flagellum biosynthesis in mucoid, nonmotile P. aeruginosa cystic fibrosis isolates by promoting expression of AmrZ, which subsequently represses fleQ [2].

High impact information on fleQ


Biological context of fleQ

  • We therefore examined the regulation of the fleSR operon by fleQ and vice versa [6].
  • Primer extension analysis of the fleQ transcript revealed two transcriptional start sites, t1 and t2, that map within the Vfr binding site [5].
  • Both of these functions were regained by providing the complete fleQ gene on a multicopy plasmid [6].
  • Except for the posttranslational downregulation of FleQ activity by FleN, an antiactivator, not much is known about the regulation of the fleQ gene or its gene product [5].
  • The complete nucleotide sequence of the fleQ gene was determined on both DNA strands, and an open reading frame (ORF) consisting of 1,493 nucleotides was identified [6].

Other interactions of fleQ


Analytical, diagnostic and therapeutic context of fleQ

  • Electrophoretic mobility shift assays using purified AlgT and extracts derived from isogenic AlgT(+) and AlgT(-) strains revealed that AlgT inhibits fleQ indirectly [2].


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