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pchA  -  salicylate biosynthesis isochorismate...

Pseudomonas aeruginosa PAO1

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High impact information on pchA

  • In cultures grown in iron-limiting media to high cell densities, overexpression of the pchA gene resulted in overproduction of salicylate as well as in enhanced pyochelin formation [1].
  • This enzyme is encoded by pchA, the last gene in the pchDCBA operon [1].
  • The pchB stop codon overlaps the presumed pchA start codon [2].

Associations of pchA with chemical compounds

  • To elucidate the salicylate biosynthetic pathway, we have cloned and sequenced a chromosomal region of P. aeruginosa PAO1 containing two adjacent genes, designated pchB and pchA, which are necessary for salicylate formation [2].
  • The pchA gene encodes a protein of 52 kDa with extensive similarity to the chorismate-utilizing enzymes isochorismate synthase, anthranilate synthase (component I) and p-aminobenzoate synthase (component I), whereas the 11 kDa protein encoded by pchB does not show significant similarity with other proteins [2].


  1. Isochorismate synthase (PchA), the first and rate-limiting enzyme in salicylate biosynthesis of Pseudomonas aeruginosa. Gaille, C., Reimmann, C., Haas, D. J. Biol. Chem. (2003) [Pubmed]
  2. Structural genes for salicylate biosynthesis from chorismate in Pseudomonas aeruginosa. Serino, L., Reimmann, C., Baur, H., Beyeler, M., Visca, P., Haas, D. Mol. Gen. Genet. (1995) [Pubmed]
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