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Chemical Compound Review

Papacidium     4-aminobenzoate

Synonyms: AG-K-79680, CHEBI:17836, AC1Q5BFN, BBL002897, CTK4G2670, ...
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Disease relevance of Potaba


High impact information on Potaba


Chemical compound and disease context of Potaba


Biological context of Potaba


Anatomical context of Potaba

  • Incubation of liver cytosol from mutant A and B6.A mice at 37 degrees C for 6 hr resulted in virtual cessation of p-aminobenzoate N-acetylation activity, whereas the steady-state level of immunoreactive NAT2 remained unchanged [18].
  • Culturing HL-60 cells in the presence of p-aminobenzoate, a competitive inhibitor of polyprenyl-4-hydroxybenzoate transferase (Coq2p), produced a significant decrease of CoQ(10) levels without affecting cell viability [19].

Associations of Potaba with other chemical compounds

  • In some micro-organisms, p-aminobenzoate synthase and anthranilate synthase share a common glutamine amidotransferase subunit [3].
  • For p-aminobenzoate, its three most intense Raman features, due to a phenyl mode (1607 cm-1) and carboxylate stretching (1383 cm-1) and scissoring (863 cm-1) motions, are little perturbed upon binding and show no changes in the pH range 6.5-8 [20].
  • The strategy included releasing the oligosaccharides by digestion of the purified glycoprotein with endoglycosidase H, separating the released oligosaccharides by high resolution gel filtration, and derivatizing the resulting reducing termini with the uv-absorbing moiety, ethyl p-aminobenzoate [21].
  • Homology of pyridoxal-5'-phosphate-dependent aminotransferases with the cobC (cobalamin synthesis), nifS (nitrogen fixation), pabC (p-aminobenzoate synthesis) and malY (abolishing endogenous induction of the maltose system) gene products [22].
  • Equilibrium solubilities of the first four homologous alkyl p-aminobenzoate esters were determined in methanol, ethanol, and 1-propanol at 25, 33, and 40 degrees; the esters and the alcohols comprise separate homologous series [23].

Gene context of Potaba


Analytical, diagnostic and therapeutic context of Potaba


  1. Safety, infectivity, immunogenicity, and in vivo stability of two attenuated auxotrophic mutant strains of Salmonella typhi, 541Ty and 543Ty, as live oral vaccines in humans. Levine, M.M., Herrington, D., Murphy, J.R., Morris, J.G., Losonsky, G., Tall, B., Lindberg, A.A., Svenson, S., Baqar, S., Edwards, M.F. J. Clin. Invest. (1987) [Pubmed]
  2. p-Aminobenzoate synthesis in Escherichia coli: purification and characterization of PabB as aminodeoxychorismate synthase and enzyme X as aminodeoxychorismate lyase. Ye, Q.Z., Liu, J., Walsh, C.T. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  3. Evolution of glutamine amidotransferase genes. Nucleotide sequences of the pabA genes from Salmonella typhimurium, Klebsiella aerogenes and Serratia marcescens. Kaplan, J.B., Merkel, W.K., Nichols, B.P. J. Mol. Biol. (1985) [Pubmed]
  4. Regulation of a common amidotransferase subunit. Kane, J.F. J. Bacteriol. (1977) [Pubmed]
  5. Evolutionary differences in chromosomal locations of four early genes of the tryptophan pathway in fluorescent pseudomonads: DNA sequences and characterization of Pseudomonas putida trpE and trpGDC. Essar, D.W., Eberly, L., Crawford, I.P. J. Bacteriol. (1990) [Pubmed]
  6. Folate synthesis in plants: the p-aminobenzoate branch is initiated by a bifunctional PabA-PabB protein that is targeted to plastids. Basset, G.J., Quinlivan, E.P., Ravanel, S., Rébeillé, F., Nichols, B.P., Shinozaki, K., Seki, M., Adams-Phillips, L.C., Giovannoni, J.J., Gregory, J.F., Hanson, A.D. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  7. p-Aminobenzoate biosynthesis in Escherichia coli. Purification of aminodeoxychorismate lyase and cloning of pabC. Green, J.M., Nichols, B.P. J. Biol. Chem. (1991) [Pubmed]
  8. A monoclonal antibody recognizing the FAD-binding site of 4-aminobenzoate hydroxylase from Agaricus bisporus. Tsuji, H., Ogawa, T., Bando, N., Kimoto, M., Sasaoka, K. J. Biol. Chem. (1990) [Pubmed]
  9. Sequence of the small subunit of yeast carbamyl phosphate synthetase and identification of its catalytic domain. Nyunoya, H., Lusty, C.J. J. Biol. Chem. (1984) [Pubmed]
  10. para-aminobenzoate synthesis from chorismate occurs in two steps. Nichols, B.P., Seibold, A.M., Doktor, S.Z. J. Biol. Chem. (1989) [Pubmed]
  11. Characterization of mutations that allow p-aminobenzoyl-glutamate utilization by Escherichia coli. Hussein, M.J., Green, J.M., Nichols, B.P. J. Bacteriol. (1998) [Pubmed]
  12. Purification of Escherichia coli B-specific p-aminobenzoate "pick-up" protein to homogeneity by affinity chromatography. Toth-Martinez, B.L., Dinya, Z., Hernádi, F. J. Chromatogr. (1975) [Pubmed]
  13. Continuous degradation of mixtures of 4-nitrobenzoate and 4-aminobenzoate by immobilized cells of Burkholderia cepacia strain PB4. Peres, C.M., Van Aken, B., Naveau, H., Agathos, S.N. Appl. Microbiol. Biotechnol. (1999) [Pubmed]
  14. Crystal structures of wild-type p-hydroxybenzoate hydroxylase complexed with 4-aminobenzoate,2,4-dihydroxybenzoate, and 2-hydroxy-4-aminobenzoate and of the Tyr222Ala mutant complexed with 2-hydroxy-4-aminobenzoate. Evidence for a proton channel and a new binding mode of the flavin ring. Schreuder, H.A., Mattevi, A., Obmolova, G., Kalk, K.H., Hol, W.G., van der Bolt, F.J., van Berkel, W.J. Biochemistry (1994) [Pubmed]
  15. Potent inhibition of endopeptidase 24.16 and endopeptidase 24.15 by the phosphonamide peptide N-(phenylethylphosphonyl)-Gly-L-Pro-L-aminohexanoic acid. Barelli, H., Dive, V., Yiotakis, A., Vincent, J.P., Checler, F. Biochem. J. (1992) [Pubmed]
  16. Nucleotide sequence of Escherichia coli pabB indicates a common evolutionary origin of p-aminobenzoate synthetase and anthranilate synthetase. Goncharoff, P., Nichols, B.P. J. Bacteriol. (1984) [Pubmed]
  17. J-Hydroxybenzoate: polyprenyl transferase and the prenylation of 4-aminobenzoate in mammalian tissues. Alam, S.S., Nambudiri, A.M., Rudney, H. Arch. Biochem. Biophys. (1975) [Pubmed]
  18. Slow acetylation in mice is caused by a labile and catalytically impaired mutant N-acetyltransferase (NAT2 9). De Leon, J.H., Martell, K.J., Vatsis, K.P., Weber, W.W. Drug Metab. Dispos. (1995) [Pubmed]
  19. Coenzyme Q and the regulation of intracellular steady-state levels of superoxide in HL-60 cells. González-Aragón, D., Burón, M.I., López-Lluch, G., Hermán, M.D., Gómez-Díaz, C., Navas, P., Villalba, J.M. Biofactors (2005) [Pubmed]
  20. Probing the chemistries of the substrate and flavin ring system of p-hydroxybenzoate hydroxylase by raman difference spectroscopy. Clarkson, J., Palfey, B.A., Carey, P.R. Biochemistry (1997) [Pubmed]
  21. Structural characterization of intact, branched oligosaccharides by high performance liquid chromatography and liquid secondary ion mass spectrometry. Webb, J.W., Jiang, K., Gillece-Castro, B.L., Tarentino, A.L., Plummer, T.H., Byrd, J.C., Fisher, S.J., Burlingame, A.L. Anal. Biochem. (1988) [Pubmed]
  22. Homology of pyridoxal-5'-phosphate-dependent aminotransferases with the cobC (cobalamin synthesis), nifS (nitrogen fixation), pabC (p-aminobenzoate synthesis) and malY (abolishing endogenous induction of the maltose system) gene products. Mehta, P.K., Christen, P. Eur. J. Biochem. (1993) [Pubmed]
  23. Solution thermodynamics of alkyl p-aminobenzoates. Schwartz, P.A., Paruta, A.N. Journal of pharmaceutical sciences. (1976) [Pubmed]
  24. Nucleotide sequences of fic and fic-1 genes involved in cell filamentation induced by cyclic AMP in Escherichia coli. Kawamukai, M., Matsuda, H., Fujii, W., Utsumi, R., Komano, T. J. Bacteriol. (1989) [Pubmed]
  25. Purification and characterization of human serum biotinidase. Chauhan, J., Dakshinamurti, K. J. Biol. Chem. (1986) [Pubmed]
  26. Quinazoline antifolate thymidylate synthase inhibitors: difluoro-substituted benzene ring analogues. Thornton, T.J., Jackman, A.L., Marsham, P.R., O'Connor, B.M., Bishop, J.A., Calvert, A.H. J. Med. Chem. (1992) [Pubmed]
  27. Quinazoline antifolate thymidylate synthase inhibitors: bridge modifications and conformationally restricted analogues in the C2-methyl series. Marsham, P.R., Jackman, A.L., Hayter, A.J., Daw, M.R., Snowden, J.L., O'Connor, B.M., Bishop, J.A., Calvert, A.H., Hughes, L.R. J. Med. Chem. (1991) [Pubmed]
  28. Rapid sample preparation and high performance liquid chromatographic determination of total and unbound serum disopyramide. Taylor, E.H., Nelson, D., Taylor, R.D., Pappas, A.A. Therapeutic drug monitoring. (1986) [Pubmed]
  29. A capillary electrophoretic study on the specificity of beta-galactosidases from Aspergillus oryzae, Escherichia coli, Streptococcus pneumoniae, and Canavalia ensiformis (jack bean). Zeleny, R., Altmann, F., Praznik, W. Anal. Biochem. (1997) [Pubmed]
  30. Association-dissociation of the flavoprotein hog kidney D-amino acid oxidase. Determination of the monomer-dimer equilibrium constant and the energetics of subunit association. Horiike, K., Shiga, K., Nishina, Y., Isomoto, A., Yamano, T. J. Biochem. (1977) [Pubmed]
  31. Sulfa drug screening in yeast: fifteen sulfa drugs compete with p-aminobenzoate in Saccharomyces cerevisiae. Castelli, L.A., Nguyen, N.P., Macreadie, I.G. FEMS Microbiol. Lett. (2001) [Pubmed]
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