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Gene Review:

mmr - multidrug resistance protein Mmr

Mycobacterium tuberculosis H37Rv

De Rossi, E. et al., Li, X.Z. et al., Takiff, H.E. et al.

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Disease relevance of mmr

It is homologous to qacA from Staphylococcus aureus, tcmA, of Streptomyces glaucescens, and actII and mmr, both from Streptomyces coelicoler [1].
mmr, a Mycobacterium tuberculosis gene conferring resistance to small cationic dyes and inhibitors [2].

High impact information on mmr

The deletions of the lfrA gene or mmr homologue rendered the mutant more susceptible to multiple drugs such as fluoroquinolones, ethidium bromide, and acriflavine (two- to eightfold decrease in MICs) [3].
The mmr gene, cloned from Mycobacterium tuberculosis, was shown to confer to Mycobacterium smegmatis resistance to tetraphenylphosphonium (TPP), erythromycin, ethidium bromide, acriflavine, safranin O, and pyronin Y [2].

References

Efflux pump of the proton antiporter family confers low-level fluoroquinolone resistance in Mycobacterium smegmatis. Takiff, H.E., Cimino, M., Musso, M.C., Weisbrod, T., Martinez, R., Delgado, M.B., Salazar, L., Bloom, B.R., Jacobs, W.R. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
mmr, a Mycobacterium tuberculosis gene conferring resistance to small cationic dyes and inhibitors. De Rossi, E., Branzoni, M., Cantoni, R., Milano, A., Riccardi, G., Ciferri, O. J. Bacteriol. (1998) [Pubmed]
Efflux pump-mediated intrinsic drug resistance in Mycobacterium smegmatis. Li, X.Z., Zhang, L., Nikaido, H. Antimicrob. Agents Chemother. (2004) [Pubmed]

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