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Gene Review:

cagG - cag island protein

Helicobacter pylori J99

Xu, C. et al., Saito, H. et al., Hsu, P.I. et al., Mizushima, T. et al.

Xu, Li, Tu, Xu, Gong, Man,

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Disease relevance of cagG

Roles of virD4 and cagG genes in the cag pathogenicity island of Helicobacter pylori using a Mongolian gerbil model [1].
RESULTS: cagG was present in 91.7% of the 145 H pylori isolates, with the rates were 90.3%, 93.8%, 88.2% and 100.0%, respectively, in those from patients with chronic gastritis, duodenal ulcer, gastric ulcer, and gastric and duodenal ulcer [2].

High impact information on cagG

BACKGROUND AND AIMS: The roles of the virD4 and the cagG genes in the cag pathogenicity island of Helicobacter pylori for gastroduodenal pathogenesis are unclear and their roles in vivo have not been examined [1].
Although the presence of cagG was a better predictor of the presence of an intact cag PAI than cagA or cagE, the presence or absence of any of these genes had no association with clinical presentation [3].
Decreased adherence of cagG-deleted Helicobacter pylori to gastric epithelial cells in Japanese clinical isolates [4].
METHODS: cagG was amplified by polymerase chain reaction in 145 H pylori isolates cultured from patients with chronic gastritis (n=72), duodenal ulcer (n=48), gastric ulcer (n=17), or gastric and duodenal ulcer (n=8), and the relationship between cagG status and the grade of gastric mucosal inflammation was determined [2].

References

Roles of virD4 and cagG genes in the cag pathogenicity island of Helicobacter pylori using a Mongolian gerbil model. Saito, H., Yamaoka, Y., Ishizone, S., Maruta, F., Sugiyama, A., Graham, D.Y., Yamauchi, K., Ota, H., Miyagawa, S. Gut (2005) [Pubmed]
Distribution of cagG gene in Helicobacter pylori isolates from Chinese patients with different gastroduodenal diseases and its clinical and pathological significance. Xu, C., Li, Z.S., Tu, Z.X., Xu, G.M., Gong, Y.F., Man, X.H. World J. Gastroenterol. (2003) [Pubmed]
Clinical presentation in relation to diversity within the Helicobacter pylori cag pathogenicity island. Hsu, P.I., Hwang, I.R., Cittelly, D., Lai, K.H., El-Zimaity, H.M., Gutierrez, O., Kim, J.G., Osato, M.S., Graham, D.Y., Yamaoka, Y. Am. J. Gastroenterol. (2002) [Pubmed]
Decreased adherence of cagG-deleted Helicobacter pylori to gastric epithelial cells in Japanese clinical isolates. Mizushima, T., Sugiyama, T., Kobayashi, T., Komatsu, Y., Ishizuka, J., Kato, M., Asaka, M. Helicobacter (2002) [Pubmed]

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