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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SERPINB12  -  serpin peptidase inhibitor, clade B...

Homo sapiens

Synonyms: Serpin B12, YUKOPIN
 
 
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High impact information on SERPINB12

  • Based on the presence of Arg and Ser at the reactive center of the RSL, SERPINB12 appeared to be an inhibitor of trypsin-like serine proteinases [1].
  • Expression studies showed that SERPINB12 was expressed in many tissues, including brain, bone marrow, lymph node, heart, lung, liver, pancreas, testis, ovary, and intestines [1].
  • This hypothesis was confirmed because recombinant SERPINB12 inhibited human trypsin and plasmin but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator [1].
  • The Serpinb12 gene contains seven exons in the frog genome, but eight exons in chickens and humans, indicating that the additional exon evolved in this gene [2].

References

  1. SERPINB12 is a novel member of the human ov-serpin family that is widely expressed and inhibits trypsin-like serine proteinases. Askew, Y.S., Pak, S.C., Luke, C.J., Askew, D.J., Cataltepe, S., Mills, D.R., Kato, H., Lehoczky, J., Dewar, K., Birren, B., Silverman, G.A. J. Biol. Chem. (2001) [Pubmed]
  2. Analysis of vertebrate genomes suggests a new model for clade B serpin evolution. Kaiserman, D., Bird, P.I. BMC Genomics (2005) [Pubmed]
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