Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Pdk4 - pyruvate dehydrogenase kinase, isozyme 4

Rattus norvegicus

Synonyms: Pyruvate dehydrogenase kinase isoform 4

Planavila, A. et al., Holness, M.J. et al.

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Disease relevance of Pdk4

Phenylephrine-induced cardiac hypertrophy in neonatal rat cardiomyocytes caused a reduction in the expression of pyruvate dehydrogenase kinase 4 (Pdk4), a target gene of PPARbeta/delta involved in fatty acid utilization, and a fall in palmitate oxidation that was reversed by NF-kappaB inhibitors [1].

High impact information on Pdk4

Lipopolysaccharide stimulation of NF-kappaB in embryonic rat heart-derived H9c2 myotubes, which only express PPARbeta/delta, caused both a reduction in Pdk4 expression and DNA binding activity of PPARbeta/delta to its response element, effects that were reversed by NF-kappaB inhibitors [1].
Up-regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) protein expression in oxidative skeletal muscle does not require the obligatory participation of peroxisome-proliferator-activated receptor alpha (PPARalpha) [2].

References

Nuclear factor-kappaB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy. Planavila, A., Laguna, J.C., Vázquez-Carrera, M. J. Biol. Chem. (2005) [Pubmed]
Up-regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) protein expression in oxidative skeletal muscle does not require the obligatory participation of peroxisome-proliferator-activated receptor alpha (PPARalpha). Holness, M.J., Bulmer, K., Gibbons, G.F., Sugden, M.C. Biochem. J. (2002) [Pubmed]

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