Disease relevance of C19orf6

• Identification and characterization of membralin, a novel tumor-associated gene, in ovarian carcinoma [1].
• Based on quantitative real-time PCR, in situ hybridization and Western blot analysis, membralin was highly expressed in ovarian serous carcinomas as compared to ovarian surface epithelium (P<0.001) [1].

High impact information on C19orf6

• The long form of membralin (membralin-1) comprises all 11 exons, encoding a protein of 620-amino acids long and the short form of membralin (membralin-3) contains all exons except for exon 10, encoding a protein of 408 amino acids [1].
• Human membralin is unique and does not share significant sequence homology with other human genes, only membralins of other species [1].
• The human gene C19orf6 localizes to chromosome 19p13 [2].

Anatomical context of C19orf6

• A novel gene, membralin (GeneBank accession number: DQ005958), was cloned from a human ovarian cancer cell line [1].

References