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Gene Review:

hfq - RNA-binding protein Hfq

Escherichia coli O157:H7 str. Sakai

Drepper, T. et al., Christiansen, J.K. et al., Geissmann, T.A. et al., Vytvytska, O. et al., Shi, X. et al., et al.

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Disease relevance of ECs5148

The Sm-like protein Hfq is involved in post-transcriptional regulation by small, noncoding RNAs in Escherichia coli that act by base pairing [1].
Another group was found to carry the hfq gene, which encodes the host factor HF-1 for bacteriophage Q beta replication [2].

High impact information on ECs5148

Recently, host factor I (Hfq/HF1) was shown to be involved in the regulation of ompA mRNA stability under slow growth conditions [3].
The Sm-like protein Hfq regulates polyadenylation dependent mRNA decay in Escherichia coli [4].
The RNA-binding protein Hfq plays important roles in bacterial physiology and is required for the activity of many small regulatory RNAs in prokaryotes [5].
Thus, an hfq mutant of MC4100 is devoid of FNR protein and has the phenotype of an fnr mutant [6].
The Rhodobacter capsulatus nrfA gene product exhibits extensive similarity to the nif (nitrogen fixation) regulatory factor NrfA of Azorhizobium caulinodans and the nucleoid-associated protein Hfq of Escherichia coli [7].

References

Hfq, a new chaperoning role: binding to messenger RNA determines access for small RNA regulator. Geissmann, T.A., Touati, D. EMBO J. (2004) [Pubmed]
Plasmids bearing hfq and the hns-like gene stpA complement hns mutants in modulating arginine decarboxylase gene expression in Escherichia coli. Shi, X., Bennett, G.N. J. Bacteriol. (1994) [Pubmed]
Hfq (HF1) stimulates ompA mRNA decay by interfering with ribosome binding. Vytvytska, O., Moll, I., Kaberdin, V.R., von Gabain, A., Bläsi, U. Genes Dev. (2000) [Pubmed]
The Sm-like protein Hfq regulates polyadenylation dependent mRNA decay in Escherichia coli. Mohanty, B.K., Maples, V.F., Kushner, S.R. Mol. Microbiol. (2004) [Pubmed]
Identification of small Hfq-binding RNAs in Listeria monocytogenes. Christiansen, J.K., Nielsen, J.S., Ebersbach, T., Valentin-Hansen, P., Søgaard-Andersen, L., Kallipolitis, B.H. RNA (2006) [Pubmed]
Expression of fnr is constrained by an upstream IS5 insertion in certain Escherichia coli K-12 strains. Sawers, R.G. J. Bacteriol. (2005) [Pubmed]
The Hfq-like protein NrfA of the phototrophic purple bacterium Rhodobacter capsulatus controls nitrogen fixation via regulation of nifA and anfA expression. Drepper, T., Raabe, K., Giaourakis, D., Gendrullis, M., Masepohl, B., Klipp, W. FEMS Microbiol. Lett. (2002) [Pubmed]

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