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Gene Review:

SlnVgp086 - ORF86

Spodoptera litura nucleopolyhedrovirus

Kamita, S.G. et al., Chen, T. et al., Ito, E. et al., McDougal, V.V. et al., Bideshi, D.K. et al., et al.

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Disease relevance of SlnVgp086

The Autographa californica nuclear polyhedrosis virus p143 gene encodes a DNA helicase [1].
DNA and ATP binding activities of the baculovirus DNA helicase P143 [2].
DNA-independent ATPase activity of the Trichoplusia ni granulovirus DNA helicase [3].

High impact information on SlnVgp086

The baculovirus protein P143 is essential for viral DNA replication in vivo, likely as a DNA helicase [4].
Homologous recombination between the Autographa californica nuclear polyhedrosis virus (AcNPV) genome and a 0.6-kbp-long DNA fragment derived from the putative DNA helicase gene of Bombyx mori nuclear polyhedrosis virus generates eh2-AcNPV, an expanded-host-range AcNPV mutant (S. Maeda, S.G. Kamita, and A. Kondo, J. Virol. 67:6234-6238, 1993) [5].
LEF-3 is a single-stranded DNA binding protein (SSB) and P143 is a DNA helicase protein [6].

References

The Autographa californica nuclear polyhedrosis virus p143 gene encodes a DNA helicase. McDougal, V.V., Guarino, L.A. J. Virol. (2000) [Pubmed]
DNA and ATP binding activities of the baculovirus DNA helicase P143. McDougal, V.V., Guarino, L.A. J. Virol. (2001) [Pubmed]
DNA-independent ATPase activity of the Trichoplusia ni granulovirus DNA helicase. Bideshi, D.K., Federici, B.A. J. Gen. Virol. (2000) [Pubmed]
Characterization of the interaction between P143 and LEF-3 from two different baculovirus species: Choristoneura fumiferana nucleopolyhedrovirus LEF-3 can complement Autographa californica nucleopolyhedrovirus LEF-3 in supporting DNA replication. Chen, T., Sahri, D., Carstens, E.B. J. Virol. (2004) [Pubmed]
Abortive infection of the baculovirus Autographa californica nuclear polyhedrosis virus in Sf-9 cells after mutation of the putative DNA helicase gene. Kamita, S.G., Maeda, S. J. Virol. (1996) [Pubmed]
Baculovirus proteins IE-1, LEF-3, and P143 interact with DNA in vivo: a formaldehyde cross-linking study. Ito, E., Sahri, D., Knippers, R., Carstens, E.B. Virology (2004) [Pubmed]

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