High impact information on SNORD22

• Thus, the introns rather than the exons specify the functional products of UHG [1].
• The spliced UHG RNA, although it is associated with polysomes, has little potential for protein coding, is short-lived, and is poorly conserved between human and mouse [1].
• Depletion of U22 from Xenopus oocytes by oligonucleotide-directed ribonuclease H targeting prevented the processing of 18S ribosomal RNA (rRNA) at both ends [2].
• FDG (370 MBq) was injected intravenously after 75-g oral glucose loading, and PET, UHGP SPECT and DCD-I were performed 45, 60 and 210 min, respectively, after the injection [3].
• In all cases, identification of multiple disease-associated genotypes is possible using a single UHG [4].

Biological context of SNORD22

• The stable RNA products from this locus are actually encoded within eight different introns of the UHG pre-RNA [5].
• We also investigated the possibility that the expression of UHG was subject to genomic imprinting [5].
• In order to more fully characterize the locus, we have mapped UHG to chromosome 11q13 by fluorescence in situ hybridization (FISH) [5].
• Point mutation screening methods AMD, CSGE, DGGE, SSCP and UHG analysis are also detailed [6].

Associations of SNORD22 with chemical compounds

• However, for the Aeroneb Pro small mesh and Omron NE U22, the use of sucrose solution tended to increase droplet VMD, and reduce aerosol mass and phospholipid outputs from the nebulizers [7].

Analytical, diagnostic and therapeutic context of SNORD22

• The method involves PCR amplification of the target exon and hybridization with a PCR-amplifiable synthetic DNA (universal heteroduplex generator, UHG) [8].
• Agreement between UHGP SPECT and PET was 55.0% [3].

References