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Gene Review: 

HHV8gp82  -  ORF K15

Human herpesvirus 8 type M

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Disease relevance of HHV8gp82

 

High impact information on HHV8gp82

  • In addition, two alternative highly diverged forms of the complex spliced ORF-K15 gene (P or M) map at the extreme RHS of the genome and are essentially unlinked to the ORF-K1 genotypes [2].
  • However, chimeric genomes have also been detected, especially with regard to the presence of P versus M alleles of the ORF-K15 gene [3].
 

Analytical, diagnostic and therapeutic context of HHV8gp82

  • STUDY DESIGN: Direct PCR DNA sequencing was carried out on the ORF-K1 and ORF-K15 genes at the extreme left and right hand sides, as well as on six other internal loci of diagnostic samples collected from 70 new KSHV-positive patients in Israel, South Korea, Sicily, Scandinavia, Brazil, Uganda, South Africa and the US [3].

References

  1. Distinct distribution of rare US genotypes of Kaposi's sarcoma-associated herpesvirus (KSHV) in South Texas: implications for KSHV epidemiology. Zhang, Y.J., Davis, T.L., Wang, X.P., Deng, J.H., Baillargeon, J., Yeh, I.T., Jenson, H.B., Gao, S.J. J. Infect. Dis. (2001) [Pubmed]
  2. KSHV strains: the origins and global spread of the virus. Hayward, G.S. Semin. Cancer Biol. (1999) [Pubmed]
  3. Genotypic analysis at multiple loci across Kaposi's sarcoma herpesvirus (KSHV) DNA molecules: clustering patterns, novel variants and chimerism. Zong, J., Ciufo, D.M., Viscidi, R., Alagiozoglou, L., Tyring, S., Rady, P., Orenstein, J., Boto, W., Kalumbuja, H., Romano, N., Melbye, M., Kang, G.H., Boshoff, C., Hayward, G.S. J. Clin. Virol. (2002) [Pubmed]
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