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Disease relevance of Korea


High impact information on Korea

  • OBJECTIVES: To determine whether cigarette smoking is an independent risk factor for atherosclerotic cardiovascular disease (ASCVD) in the Republic of Korea (South Korea), a population that has relatively low levels of serum cholesterol, and to determine whether serum cholesterol levels modify the risk relationship between smoking and ASCVD [6].
  • A phylogenetic analysis of the eight viral genes showed that the H5N1 poultry isolates from South Korea were of avian origin and contained the hemagglutinin and neuraminidase genes of the A/goose/Guangdong/1/96 (Gs/Gd) lineage [7].
  • 40 years after the first report about its biological activity, carboplatin and oxaliplatin are in routine clinical use today, whereas nedaplatin, lobaplatin, and heptaplatin (SKI2053R) are only approved in Japan, China, and South Korea, respectively [8].
  • A clinical comparison of definite moyamoya disease between South Korea and Japan [9].
  • Of 347 (25.6%) MRSA isolates that grew on the screening agar plates, 58 isolates (4.3%) were hVISA. hVISA strains were found in India, South Korea, Japan, the Philippines, Singapore, Thailand, and Vietnam [10].

Biological context of Korea

  • One market product purchased in South Korea grouped with other haplotypes found only in the North Atlantic, suggesting a violation of current agreements banning international trade in cetacean species [11].
  • A marine bacterial strain, designated FR1311(T), was isolated from a sea-water sample from Ganghwa Island, South Korea. Cells were Gram-negative, facultatively anaerobic, catalase- and oxidase-positive, motile, oval or rod-shaped and halophilic (optimum sea-salt concentration for growth of 5-6 %) [12].
  • Induction of the P450 reporter gene system bioassay by polycyclic aromatic hydrocarbons in Ulsan Bay (South Korea) sediments [13].
  • The Korean MDHAQ was administered to 136 patients with RA who were attending the outpatient rheumatology clinic at the Chonnam National University Hospital (Gwangju, South Korea) [14].

Anatomical context of Korea

  • New inactivated JE vaccines manufactured in Vero cells are in advanced preclinical or early clinical development in Japan, South Korea, Taiwan, and the PRC [15].

Associations of Korea with chemical compounds

  • CONCLUSIONS: YMDD mutants in HBV were detected within a few weeks during lamivudine therapy in South Korea, which suggests that the YMDD mutant may exist even before lamivudine therapy in HBV endemic areas [16].
  • Marked geographical differences in the prevalence of both penicillin G (the Netherlands 0%; South Korea 71.5%) and erythromycin A (Sweden 4.7%; South Korea 87.6%) resistance were observed [17].
  • A 1.8 angstroms data set has been collected using synchrotron radiation at Pohang Light Source, South Korea. The crystal belongs to the monoclinic space group C2, with unit-cell parameters a = 77.2, b = 31.8, c = 33.6 angstroms, beta = 105.1 degrees [18].
  • According to the Science Citation Index database, over 50 papers related to drug delivery have been published from South Korea during the last 3 years [19].
  • A Gram-negative, strictly anaerobic, halophilic, motile, sporulating and rod-shaped bacterium, designated strain HY-42-06(T), was isolated from tidal flat sediment from Ganghwa Island in South Korea. The isolate produced glycerol, ethanol and CO(2) as fermentation end-products from glucose [20].

Gene context of Korea


Analytical, diagnostic and therapeutic context of Korea


  1. Clonal dissemination and mupA gene polymorphism of mupirocin-resistant Staphylococcus aureus isolates from long-term-care facilities in South Korea. Yoo, J.I., Shin, E.S., Cha, J.O., Lee, J.K., Jung, Y.H., Lee, K.M., Kim, B.S., Lee, Y.S. Antimicrob. Agents Chemother. (2006) [Pubmed]
  2. Molecular analysis of isoniazid resistance in Mycobacterium tuberculosis isolates recovered from South Korea. Kim, S.Y., Park, Y.J., Kim, W.I., Lee, S.H., Ludgerus Chang, C., Kang, S.J., Kang, C.S. Diagn. Microbiol. Infect. Dis. (2003) [Pubmed]
  3. Persistent diplopia after retrobulbar anesthesia. Han, S.K., Kim, J.H., Hwang, J.M. Journal of cataract and refractive surgery. (2004) [Pubmed]
  4. A comparative trial of a single dose of azithromycin versus doxycycline for the treatment of mild scrub typhus. Kim, Y.S., Yun, H.J., Shim, S.K., Koo, S.H., Kim, S.Y., Kim, S. Clin. Infect. Dis. (2004) [Pubmed]
  5. Detection of hepatitis B virus variants resistant to lamivudine and famciclovir among randomly selected chronic carriers from Spain. León, P., Pozo, F., Echevarría, J.M. Enferm. Infecc. Microbiol. Clin. (2004) [Pubmed]
  6. Smoking and atherosclerotic cardiovascular disease in men with low levels of serum cholesterol: the Korea Medical Insurance Corporation Study. Jee, S.H., Suh, I., Kim, I.S., Appel, L.J. JAMA (1999) [Pubmed]
  7. Characterization of highly pathogenic H5N1 avian influenza A viruses isolated from South Korea. Lee, C.W., Suarez, D.L., Tumpey, T.M., Sung, H.W., Kwon, Y.K., Lee, Y.J., Choi, J.G., Joh, S.J., Kim, M.C., Lee, E.K., Park, J.M., Lu, X., Katz, J.M., Spackman, E., Swayne, D.E., Kim, J.H. J. Virol. (2005) [Pubmed]
  8. Update of the preclinical situation of anticancer platinum complexes: novel design strategies and innovative analytical approaches. Galanski, M., Jakupec, M.A., Keppler, B.K. Current medicinal chemistry. (2005) [Pubmed]
  9. A clinical comparison of definite moyamoya disease between South Korea and Japan. Ikezaki, K., Han, D.H., Kawano, T., Kinukawa, N., Fukui, M. Stroke (1997) [Pubmed]
  10. Emergence in Asian countries of Staphylococcus aureus with reduced susceptibility to vancomycin. Song, J.H., Hiramatsu, K., Suh, J.Y., Ko, K.S., Ito, T., Kapi, M., Kiem, S., Kim, Y.S., Oh, W.S., Peck, K.R., Lee, N.Y. Antimicrob. Agents Chemother. (2004) [Pubmed]
  11. Worldwide structure of mtDNA diversity among Cuvier's beaked whales (Ziphius cavirostris): implications for threatened populations. Dalebout, M.L., Robertson, K.M., Frantzis, A., Engelhaupt, D., Mignucci-Giannoni, A.A., Rosario-Delestre, R.J., Baker, C.S. Mol. Ecol. (2005) [Pubmed]
  12. Photobacterium ganghwense sp. nov., a halophilic bacterium isolated from sea water. Park, Y.D., Baik, K.S., Seong, C.N., Bae, K.S., Kim, S., Chun, J. Int. J. Syst. Evol. Microbiol. (2006) [Pubmed]
  13. Induction of the P450 reporter gene system bioassay by polycyclic aromatic hydrocarbons in Ulsan Bay (South Korea) sediments. Koh, C.H., Kim, G.B., Maruya, K.A., Anderson, J.W., Jones, J.M., Kang, S.G. Environ. Pollut. (2001) [Pubmed]
  14. Evaluating the Korean version of the Multidimensional Health Assessment Questionnaire in patients with rheumatoid arthritis. Lee, S.S., Park, M.J., Yoon, H.J., Park, Y.W., Park, I.H., Park, K.S. Clin. Rheumatol. (2006) [Pubmed]
  15. Japanese encephalitis vaccines: current vaccines and future prospects. Monath, T.P. Curr. Top. Microbiol. Immunol. (2002) [Pubmed]
  16. Emergence of YMDD motif mutant of hepatitis B virus during short-term lamivudine therapy in South Korea. Paik, Y.H., Chung, H.Y., Ryu, W.S., Lee, K.S., Lee, J.S., Kim, J.H., Lee, C.K., Chon, C.Y., Moon, Y.M., Han, K.H. J. Hepatol. (2001) [Pubmed]
  17. Increasing prevalence of antimicrobial resistance among isolates of Streptococcus pneumoniae from the PROTEKT surveillance study, and compatative in vitro activity of the ketolide, telithromycin. Felmingham, D., Reinert, R.R., Hirakata, Y., Rodloff, A. J. Antimicrob. Chemother. (2002) [Pubmed]
  18. Crystallization and preliminary X-ray crystallographic analysis of the DNA-binding domain of BldD from Streptomyces coelicolor A3(2). Kim, I.K., Kim, M.K., Lee, C.J., Yim, H.S., Cha, S.S., Kang, S.O. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
  19. Future drug delivery research in South Korea. Chung, S.J. Journal of controlled release : official journal of the Controlled Release Society. (1999) [Pubmed]
  20. Clostridium ganghwense sp. nov., isolated from tidal flat sediment. Kim, S., Jeong, H., Kim, S., Chun, J. Int. J. Syst. Evol. Microbiol. (2006) [Pubmed]
  21. Identification of EGFR kinase domain mutations among lung cancer patients in China: implication for targeted cancer therapy. Qin, B.M., Chen, X., Zhu, J.D., Pei, D.Q. Cell Res. (2005) [Pubmed]
  22. Two cases of Chromobacterium violaceum infection after injury in a subtropical region. Lee, J., Kim, J.S., Nahm, C.H., Choi, J.W., Kim, J., Pai, S.H., Moon, K.H., Lee, K., Chong, Y. J. Clin. Microbiol. (1999) [Pubmed]
  23. Prevalence of major depressive disorder in the general population of South Korea. Ohayon, M.M., Hong, S.C. Journal of psychiatric research. (2006) [Pubmed]
  24. Immunization of hospital personnel with low-dose intradermal hepatitis B vaccine. Elavia, A.J., Marfatia, S.P., Banker, D.D. Vaccine (1994) [Pubmed]
  25. Global distribution of Streptococcus pneumoniae serotypes isolated from paediatric patients during 1999-2000 and the in vitro efficacy of telithromycin and comparators. Farrell, D.J., Jenkins, S.G., Reinert, R.R. J. Med. Microbiol. (2004) [Pubmed]
  26. Associations of lead biomarkers with renal function in Korean lead workers. Weaver, V.M., Lee, B.K., Ahn, K.D., Lee, G.S., Todd, A.C., Stewart, W.F., Wen, J., Simon, D.J., Parsons, P.J., Schwartz, B.S. Occupational and environmental medicine. (2003) [Pubmed]
  27. Prophylactic efficacy of lithium administered every second day: a WHO multicentre study. Plenge, P., Amin, M., Agarwal, A.K., Greil, W., Kim, M.J., Panteleyeva, G., Park, J.M., Prilipko, L., Rayushkin, V., Sharma, M., Mellerup, E. Bipolar disorders. (1999) [Pubmed]
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