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Gene Review

RECQL5  -  RecQ protein-like 5

Homo sapiens

Synonyms: ATP-dependent DNA helicase Q5, DNA helicase, RecQ-like type 5, FLJ90603, RECQ5, RecQ5
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High impact information on RECQL5


Biological context of RECQL5


Physical interactions of RECQL5

  • To understand how RECQL5 regulates HR, we use purified proteins to demonstrate that human RECQL5 binds the Rad51 recombinase and inhibits Rad51-mediated D-loop formation [6].


  1. Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome. Kitao, S., Shimamoto, A., Goto, M., Miller, R.W., Smithson, W.A., Lindor, N.M., Furuichi, Y. Nat. Genet. (1999) [Pubmed]
  2. Cloning, genomic structure and chromosomal localization of the gene encoding mouse DNA helicase RECQL5beta. Ohhata, T., Araki, R., Fukumura, R., Kuroiwa, A., Matsuda, Y., Abe, M. Gene (2001) [Pubmed]
  3. Deficiency of Caenorhabditis elegans RecQ5 homologue reduces life span and increases sensitivity to ionizing radiation. Jeong, Y.S., Kang, Y., Lim, K.H., Lee, M.H., Lee, J., Koo, H.S. DNA Repair (Amst.) (2003) [Pubmed]
  4. Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta. Shimamoto, A., Nishikawa, K., Kitao, S., Furuichi, Y. Nucleic Acids Res. (2000) [Pubmed]
  5. Drosophila and human RecQ5 exist in different isoforms generated by alternative splicing. Sekelsky, J.J., Brodsky, M.H., Rubin, G.M., Hawley, R.S. Nucleic Acids Res. (1999) [Pubmed]
  6. RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments. Hu, Y., Raynard, S., Sehorn, M.G., Lu, X., Bussen, W., Zheng, L., Stark, J.M., Barnes, E.L., Chi, P., Janscak, P., Jasin, M., Vogel, H., Sung, P., Luo, G. Genes Dev. (2007) [Pubmed]
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