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Gene Review:

EPSTI1 - epithelial stromal interaction 1 (breast)

Homo sapiens

Synonyms: BRESI1, Epithelial-stromal interaction protein 1, MGC29634

Nielsen, H.L. et al., Ishii, T. et al., Gudjonsson, T. et al.

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Disease relevance of EPSTI1

3. EPSTI1 was highly upregulated in invasive breast carcinomas compared with normal breast [1].
Identification of EPSTI1, a novel gene induced by epithelial-stromal interaction in human breast cancer [1].
Thus, EPSTI1 is a novel human gene expressed in tissues characterized by extensive epithelial-stromal interaction, and expression of this gene may be a crucial event in invasion and metastasis of cancer [1].

High impact information on EPSTI1

EPSTI1 showed no homology to any known gene, but matched a cluster of expressed-sequence tags (ESTs) [1].
As for the consequence of interaction of tumor cells with connective tissue fibroblasts, the assay allowed us to identify a hitherto undescribed gene referred to as EPSTI1 [2].
We correlated changes in gene expression and clinical/laboratory features of SLE and found that expression of ISG20, EPSTI1 and SLED1 are significantly correlated with lymphocyte counts [3].

References

Identification of EPSTI1, a novel gene induced by epithelial-stromal interaction in human breast cancer. Nielsen, H.L., Rønnov-Jessen, L., Villadsen, R., Petersen, O.W. Genomics (2002) [Pubmed]
To create the correct microenvironment: three-dimensional heterotypic collagen assays for human breast epithelial morphogenesis and neoplasia. Gudjonsson, T., Rønnov-Jessen, L., Villadsen, R., Bissell, M.J., Petersen, O.W. Methods (2003) [Pubmed]
Isolation and expression profiling of genes upregulated in the peripheral blood cells of systemic lupus erythematosus patients. Ishii, T., Onda, H., Tanigawa, A., Ohshima, S., Fujiwara, H., Mima, T., Katada, Y., Deguchi, H., Suemura, M., Miyake, T., Miyatake, K., Kawase, I., Zhao, H., Tomiyama, Y., Saeki, Y., Nojima, H. DNA Res. (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

EPSTI1	Bos taurus
LOC102154313	Canis lupus familiaris
EPSTI1	Canis lupus familiaris
epsti1	Danio rerio
EPSTI1	Gallus gallus
LOC700208	Macaca mulatta
Epsti1	Mus musculus
EPSTI1	Pan troglodytes
Epsti1	Rattus norvegicus

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