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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MED7  -  mediator complex subunit 7

Homo sapiens

Synonyms: ARC34, Activator-recruited cofactor 34 kDa component, CRSP complex subunit 9, CRSP33, CRSP9, ...
 
 
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High impact information on CRSP9

  • To further understand the structural and functional diversity of these complexes we established three HeLa cell lines each expressing one of three epitope-tagged human TRAP/Mediator subunits, MED6, MED7, and CDK8 and isolated the complexes in which these subunits were contained by affinity and HPLC-gel filtration chromatography [1].
  • The MED-7 transcriptional mediator encoded by let-49 is required for gonad and germ cell development in Caenorhabditis elegans [2].

References

  1. A kinase subunit of the human mediator complex, CDK8, positively regulates transcriptional activation. Furumoto, T., Tanaka, A., Ito, M., Malik, S., Hirose, Y., Hanaoka, F., Ohkuma, Y. Genes Cells (2007) [Pubmed]
  2. The MED-7 transcriptional mediator encoded by let-49 is required for gonad and germ cell development in Caenorhabditis elegans. Kwon, J.Y., Kim-Ha, J., Lee, B.J., Lee, J. FEBS Lett. (2001) [Pubmed]
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