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Gene Review

tsf  -  translation elongation factor EF-Ts

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0169, JW0165
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Disease relevance of tsf


High impact information on tsf

  • The data indicate that both the tsf and rpsB genes map near dapD at about 4 min on the E. coli genetic map [4].
  • These results place the part of T. thermophilus EF-Tu corresponding to the missing fragment in E. coli EF-Tu in the vicinity of the nucleotide binding site and allow its role in the interaction with aminoacyl-tRNA and elongation factor Ts to be evaluated [5].
  • The resulting EF-TuBo kirromycin and EF-TuAr EF-Ts complexes are separated by chromatography on diethylaminoethyl-Sephadex A-50 [6].
  • Role of the conserved aspartate and phenylalanine residues in prokaryotic and mitochondrial elongation factor Ts in guanine nucleotide exchange [7].
  • The dissociation rates of the nucleotides GDP and GTP appear likewise to be unaffected by the methylation, just as is the stimulatory effect of the elongation factor Ts upon these rates [8].

Biological context of tsf


Analytical, diagnostic and therapeutic context of tsf


  1. Organization and nucleotide sequence of a new ribosomal operon in Escherichia coli containing the genes for ribosomal protein S2 and elongation factor Ts. An, G., Bendiak, D.S., Mamelak, L.A., Friesen, J.D. Nucleic Acids Res. (1981) [Pubmed]
  2. A transducing bacteriophage lambda carrying the structural gene for elongation factor Ts. Friesen, J.D., Parker, J., Watson, R.J., Bendiak, D., Reeh, S.V., Pedersen, S., Fiil, N.P. Mol. Gen. Genet. (1976) [Pubmed]
  3. Elongation factor Ts from the Antarctic eubacterium Pseudoalteromonas haloplanktis TAC 125: biochemical characterization and cloning of the encoding gene. Raimo, G., Lombardo, B., Masullo, M., Lamberti, A., Longo, O., Arcari, P. Biochemistry (2004) [Pubmed]
  4. Identification of genes for elongation factor Ts and ribosomal protein S2 in E. coli. Yamamoto, M., Strycharz, W.A., Nomura, M. Cell (1976) [Pubmed]
  5. Affinity labeling of the GDP/GTP binding site in Thermus thermophilus elongation factor Tu. Peter, M.E., Wittmann-Liebold, B., Sprinzl, M. Biochemistry (1988) [Pubmed]
  6. Effects of the mutation glycine-222----aspartic acid on the functions of elongation factor Tu. Swart, G.W., Parmeggiani, A., Kraal, B., Bosch, L. Biochemistry (1987) [Pubmed]
  7. Role of the conserved aspartate and phenylalanine residues in prokaryotic and mitochondrial elongation factor Ts in guanine nucleotide exchange. Zhang, Y., Li, X., Spremulli, L.L. FEBS Lett. (1996) [Pubmed]
  8. Methylation in vivo of elongation factor EF-Tu at lysine-56 decreases the rate of tRNA-dependent GTP hydrolysis. Van Noort, J.M., Kraal, B., Sinjorgo, K.M., Persoon, N.L., Johanns, E.S., Bosch, L. Eur. J. Biochem. (1986) [Pubmed]
  9. Organization of genes in the four minute region of the Escherichia coli chromosome: evidence that rpsB and tsf are co-transcribed. Bendiak, D.S., Friesen, J.D. Mol. Gen. Genet. (1981) [Pubmed]
  10. Organization and nucleotide sequence of the genes for ribosomal protein S2 and elongation factor Ts in Spirulina platensis. Sanangelantoni, A.M., Calogero, R.C., Buttarelli, F.R., Gualerzi, C.O., Tiboni, O. FEMS Microbiol. Lett. (1990) [Pubmed]
  11. Analysis and crystallization of a 25 kDa C-terminal fragment of cloned elongation factor Ts from Escherichia coli. Bøgestrand, S., Wiborg, O., Thirup, S., Nyborg, J. FEBS Lett. (1995) [Pubmed]
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