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Gene Review

aroL  -  shikimate kinase II

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0383, JW0379
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Disease relevance of aroL


High impact information on aroL


Chemical compound and disease context of aroL

  • In this study, the physiology of a shikimic acid producing strain of Escherichia coli (derived from W3110) deleted in aroL (shikimic acid kinase II gene), was compared to that of a corresponding control strain (W3110) under carbon- and phosphate-limited conditions [7].

Biological context of aroL

  • The DNA upstream of aroL contains a number of imperfect palindromes which are closely homologous to known sites of regulation by the TyrR protein in other operons [1].
  • The 501-bp intercistronic region between aroL and aroM contains an open reading frame which might encode a 63-residue protein [1].
  • Northern blots with RNA from strains carrying multicopy aroL+ plasmids detected one longer (2,000-base) and two shorter (950- and 1,100-base) transcripts which contained aroL [1].
  • The nucleotide sequence of 2,021 base pairs (bp) of DNA containing the Escherichia coli aroLM operon was determined, and the coding regions of both aroL and aroM were identified [1].
  • In the present study, gene expression patterns of the shikimate producing strain W3110.shik1 (W3110 with aroL deletion and plasmid-overexpressed aroF) and the wild type strain W3110 grown under carbon- and phosphate-limited (carbon-rich) chemostat conditions (D=0.23h(-1)) were analyzed [8].

Other interactions of aroL


  1. Nucleotide sequence of the transcription unit containing the aroL and aroM genes from Escherichia coli K-12. DeFeyter, R.C., Davidson, B.E., Pittard, J. J. Bacteriol. (1986) [Pubmed]
  2. The cloning and expression of the aroL gene from Escherichia coli K12. Purification and complete amino acid sequence of shikimate kinase II, the aroL-gene product. Millar, G., Lewendon, A., Hunter, M.G., Coggins, J.R. Biochem. J. (1986) [Pubmed]
  3. Naturally Occurring Adenines within mRNA Coding Sequences Affect Ribosome Binding and Expression in Escherichia coli. Brock, J.E., Paz, R.L., Cottle, P., Janssen, G.R. J. Bacteriol. (2007) [Pubmed]
  4. Regulation of aroL expression by TyrR protein and Trp repressor in Escherichia coli K-12. Lawley, B., Pittard, A.J. J. Bacteriol. (1994) [Pubmed]
  5. Synergism between the Trp repressor and Tyr repressor in repression of the aroL promoter of Escherichia coli K-12. Heatwole, V.M., Somerville, R.L. J. Bacteriol. (1992) [Pubmed]
  6. Identification of the gene (aroK) encoding shikimic acid kinase I of Escherichia coli. Løbner-Olesen, A., Marinus, M.G. J. Bacteriol. (1992) [Pubmed]
  7. Shikimic acid production by a modified strain of E. coli (W3110.shik1) under phosphate-limited and carbon-limited conditions. Johansson, L., Lindskog, A., Silfversparre, G., Cimander, C., Nielsen, K.F., Lidén, G. Biotechnol. Bioeng. (2005) [Pubmed]
  8. Transcriptome analysis of a shikimic acid producing strain of Escherichia coli W3110 grown under carbon- and phosphate-limited conditions. Johansson, L., Lid??n, G. J. Biotechnol. (2006) [Pubmed]
  9. Studies of the Escherichia coli Trp repressor binding to its five operators and to variant operator sequences. Jeeves, M., Evans, P.D., Parslow, R.A., Jaseja, M., Hyde, E.I. Eur. J. Biochem. (1999) [Pubmed]
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