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Gene Review

fepA  -  ferrienterobactin outer membrane transporter

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0576, JW5086, cbr, cbt, fep, ...
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Disease relevance of fepA


High impact information on fepA

  • A portion of the remaining nucleotide sequence defined a 320-base pair control region for both the fepA and fes-entF messages [1].
  • The periplasmic protein seems to be missing from some mutants of E. coli (designated cbt) which are incapable of transporting succinate in whole cells [3].
  • In summary, the data show that in the presence of iron, cbr negatively regulates the chrysobactin biosynthetic and transport genes, while under conditions of depletion, cbr is subject to negative autogeneous regulation [4].
  • The presence of repetitive extragenic palindromic (REP) sequences within the fepA-entD intercistronic region was confirmed [5].
  • In this work seven spontaneous fepA mutations were analyzed by enzyme assay (enterobactin synthase and enterobactin esterase) and by DNA hybridization studies [6].

Chemical compound and disease context of fepA


Biological context of fepA

  • An open reading frame extending in the same direction as the adjacent fepA gene and capable of encoding an approximately 24 kDa polypeptide was found; it contained a high percentage of rare codons and two possible translational start sites [9].


  1. Transcriptional mapping and nucleotide sequence of the Escherichia coli fepA-fes enterobactin region. Identification of a unique iron-regulated bidirectional promoter. Pettis, G.S., Brickman, T.J., McIntosh, M.A. J. Biol. Chem. (1988) [Pubmed]
  2. Identification and characterization of SirA, an iron-regulated protein from Staphylococcus aureus. Heinrichs, J.H., Gatlin, L.E., Kunsch, C., Choi, G.H., Hanson, M.S. J. Bacteriol. (1999) [Pubmed]
  3. Isolation of the soluble substrate recognition component of the dicarboxylate transport system of Escherichia coli. Lo, T.C., Sanwal, B.D. J. Biol. Chem. (1975) [Pubmed]
  4. Negative transcriptional control of iron transport in Erwinia chrysanthemi involves an iron-responsive two-factor system. Expert, D., Sauvage, C., Neilands, J.B. Mol. Microbiol. (1992) [Pubmed]
  5. The Escherichia coli enterobactin biosynthesis gene, entD: nucleotide sequence and membrane localization of its protein product. Armstrong, S.K., Pettis, G.S., Forrester, L.J., McIntosh, M.A. Mol. Microbiol. (1989) [Pubmed]
  6. Biochemical analysis of spontaneous fepA mutants of Escherichia coli. Elish, M.E., Pierce, J.R., Earhart, C.F. J. Gen. Microbiol. (1988) [Pubmed]
  7. Nucleotide sequence of the gene for the ferrienterochelin receptor FepA in Escherichia coli. Homology among outer membrane receptors that interact with TonB. Lundrigan, M.D., Kadner, R.J. J. Biol. Chem. (1986) [Pubmed]
  8. The molecular mechanism of dicarboxylic acid transport in Escherichia coli K 12. Lo, T.C. J. Supramol. Struct. (1977) [Pubmed]
  9. The entD gene of the Escherichia coli K12 enterobactin gene cluster. Coderre, P.E., Earhart, C.F. J. Gen. Microbiol. (1989) [Pubmed]
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