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Gene Review

bioF  -  8-amino-7-oxononanoate synthase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0765, JW0759
 
 
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Disease relevance of bioF

 

High impact information on bioF

 

Chemical compound and disease context of bioF

 

Biological context of bioF

  • In contrast to other microorganisms, the S. meliloti bioB and bioF genes are not localized in a biotin synthesis operon, but bioB is cotranscribed with two genes coding for ABC transporter-like proteins, designated here bioM and bioN [4].
 

Associations of bioF with chemical compounds

  • Eleven biotin biosynthetic genes have been identified in Kurthia sp. Kurthia sp. has two genes coding for KAPA synthase, bioF and bioFII, and also has two genes coding for BioH protein, bioH and bioHII [7].

References

  1. Cloning and characterization of the Bacillus sphaericus genes controlling the bioconversion of pimelate into dethiobiotin. Gloeckler, R., Ohsawa, I., Speck, D., Ledoux, C., Bernard, S., Zinsius, M., Villeval, D., Kisou, T., Kamogawa, K., Lemoine, Y. Gene (1990) [Pubmed]
  2. The Escherichia coli biotin biosynthetic enzyme sequences predicted from the nucleotide sequence of the bio operon. Otsuka, A.J., Buoncristiani, M.R., Howard, P.K., Flamm, J., Johnson, C., Yamamoto, R., Uchida, K., Cook, C., Ruppert, J., Matsuzaki, J. J. Biol. Chem. (1988) [Pubmed]
  3. The crystal structure of 8-amino-7-oxononanoate synthase: a bacterial PLP-dependent, acyl-CoA-condensing enzyme. Alexeev, D., Alexeeva, M., Baxter, R.L., Campopiano, D.J., Webster, S.P., Sawyer, L. J. Mol. Biol. (1998) [Pubmed]
  4. Functional analysis of Sinorhizobium meliloti genes involved in biotin synthesis and transport. Entcheva, P., Phillips, D.A., Streit, W.R. Appl. Environ. Microbiol. (2002) [Pubmed]
  5. Characterisation of 8-amino-7-oxononanoate synthase: a bacterial PLP-dependent, acyl CoA condensing enzyme. Webster, S.P., Campopiano, D.J., Alexeev, D., Alexeeva, M., Watt, R.M., Sawyer, L., Baxter, R.L. Biochem. Soc. Trans. (1998) [Pubmed]
  6. Genetic analysis of an incomplete bio operon in a biotin auxotrophic strain of Bacillus subtilis natto OK2. Sasaki, M., Kawamura, F., Kurusu, Y. Biosci. Biotechnol. Biochem. (2004) [Pubmed]
  7. Cloning and characterization of biotin biosynthetic genes of Kurthia sp. Kiyasu, T., Nagahashi, Y., Hoshino, T. Gene (2001) [Pubmed]
 
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