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Gene Review

nfsB  -  dihydropteridine reductase, NAD(P)H...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0570, JW0567, dprA, nfnB, nfsI, ...
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Disease relevance of nfsB


High impact information on nfsB

  • While nitroreductase enzymes are widespread, nearly all the work using these in GDEPT has been with the nfsB gene product of Escherichia coli, an oxygen-insensitive flavin mononucleotide nitroreductase (NTR) [5].
  • Insertion hot spots for IS30 and IS186 are indicated in nfsA, and a hot spot for IS5 insertion is evident in nfsB [6].
  • Oxygen-insensitive nitroreductases: analysis of the roles of nfsA and nfsB in development of resistance to 5-nitrofuran derivatives in Escherichia coli [6].
  • These results suggest that the cnr gene of S. typhimurium is a counterpart of the nfsB and nfnB genes of E. coli, and that the newly constructed cnr-deletion strains are useful to assess the role of nitroreductases in the metabolic activation of mutagenic nitro compounds [7].


  1. Physical characterisation of the Escherichia coli B gene encoding nitroreductase and its over-expression in Escherichia coli K12. Michael, N.P., Brehm, J.K., Anlezark, G.M., Minton, N.P. FEMS Microbiol. Lett. (1994) [Pubmed]
  2. Gene cloning, purification, and characterization of NfsB, a minor oxygen-insensitive nitroreductase from Escherichia coli, similar in biochemical properties to FRase I, the major flavin reductase in Vibrio fischeri. Zenno, S., Koike, H., Tanokura, M., Saigo, K. J. Biochem. (1996) [Pubmed]
  3. Late expression of nitroreductase in an oncolytic adenovirus sensitizes colon cancer cells to the prodrug CB1954. Lukashev, A.N., Fuerer, C., Chen, M.J., Searle, P., Iggo, R. Hum. Gene Ther. (2005) [Pubmed]
  4. Salmonella typhimurium mutagenicity tester strains that overexpress oxygen-insensitive nitroreductases nfsA and nfsB. Carroll, C.C., Warnakulasuriyarachchi, D., Nokhbeh, M.R., Lambert, I.B. Mutat. Res. (2002) [Pubmed]
  5. Nitroreductase-based GDEPT. Denny, W.A. Curr. Pharm. Des. (2002) [Pubmed]
  6. Oxygen-insensitive nitroreductases: analysis of the roles of nfsA and nfsB in development of resistance to 5-nitrofuran derivatives in Escherichia coli. Whiteway, J., Koziarz, P., Veall, J., Sandhu, N., Kumar, P., Hoecher, B., Lambert, I.B. J. Bacteriol. (1998) [Pubmed]
  7. Targeted disruption of the gene encoding the classical nitroreductase enzyme in Salmonella typhimurium Ames test strains TA1535 and TA1538. Yamada, M., Espinosa-Aguirre, J.J., Watanabe, M., Matsui, K., Sofuni, T., Nohmi, T. Mutat. Res. (1997) [Pubmed]
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