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Gene Review

purU  -  formyltetrahydrofolate hydrolase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1227, JW1220, tgs, ychI
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Disease relevance of purU


High impact information on purU

  • The enzymes encoded by the Escherichia coli genes purU and purN, N10-formyltetrahydrofolate hydrolase and glycinamide ribonucleotide (GAR) transformylase, respectively, catalyze similiar yet distinct reactions [2].
  • A plasmid encoding ORF32 totally complemented the inability of strain DTC274 to grow on glucose minimal medium as well as the transient glycine starvation phenomenon in DTK-12, and ORF32 was designated tgs [3].
  • Partial deletion of tgs, cotransduced with the marker delta tyrT::kan, was responsible for the completely different phenotypes of the deletion mutants DTK-12 and DTC274 [3].
  • Primer extension mapping and assays of lacZ in a promoter probe vector identified two promoters giving mono- and bi-cistronic purU mRNA [1].


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