Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

ruvA - component of RuvABC resolvasome,...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1862, JW1850

Benson, F.E. et al., Ishioka, K. et al., Price, M.N. et al., Tsaneva, I.R. et al., Sharples, G.J. et al.

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Disease relevance of ruvA

BACKGROUND: All the ruvA, ruvB and ruvC mutants of Escherichia coli are sensitive to treatments that damage DNA, and are mildly defective in homologous recombination [1].

High impact information on ruvA

Increased expression of Rus suppresses the DNA repair and recombination defects of ruvA, ruvB and ruvC mutants [2].
Each of the two open reading frames, designated ruvA and ruvB, is preceded by a reasonable Shine-Dalgarno sequence [3].
CONCLUSION: ruvA, B and C mutations block chromosome partitioning in UV irradiated cells because the abortive homologous recombination covalently links chromosomes together [1].
For example, the removal of lysA and ruvA from ancestral operons that contained essential genes allowed their expression to respond to lysine levels and DNA damage, respectively [4].

Biological context of ruvA

Two 16 bp sequences (SOS boxes) that match the consensus sequence for binding LexA protein are located 5' to ruvA in a region that provides a possible single promoter for expression of both ruvA and ruvB, with the second SOS box overlapping the putative -35 region [3].
The SOS-inducible ruvA and ruvB gene products of Escherichia coli are required for normal levels of genetic recombination and DNA repair [5].

References

Abortive recombination in Escherichia coli ruv mutants blocks chromosome partitioning. Ishioka, K., Fukuoh, A., Iwasaki, H., Nakata, A., Shinagawa, H. Genes Cells (1998) [Pubmed]
Processing of intermediates in recombination and DNA repair: identification of a new endonuclease that specifically cleaves Holliday junctions. Sharples, G.J., Chan, S.N., Mahdi, A.A., Whitby, M.C., Lloyd, R.G. EMBO J. (1994) [Pubmed]
Nucleotide sequencing of the ruv region of Escherichia coli K-12 reveals a LexA regulated operon encoding two genes. Benson, F.E., Illing, G.T., Sharples, G.J., Lloyd, R.G. Nucleic Acids Res. (1988) [Pubmed]
The life-cycle of operons. Price, M.N., Arkin, A.P., Alm, E.J. PLoS Genet. (2006) [Pubmed]
RuvA and RuvB proteins of Escherichia coli exhibit DNA helicase activity in vitro. Tsaneva, I.R., Müller, B., West, S.C. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]

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