The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

ruvC  -  component of RuvABC resolvasome, endonuclease

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1864, JW1852
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ruvC


High impact information on ruvC


Biological context of ruvC

  • Multicopy plasmids expressing RusA alone make ruvA, ruvB, and ruvC mutants resistant to UV light [8].
  • The product of the ruvC gene, which is not regulated by the SOS system, resolves Holiday junctions by introducing nicks at or near the crossover junction in strands with the same polarity at the same sites [9].
  • To probe the validity of the E. coli paradigm, we examined the impact of mutations in DeltaruvAB and DeltarecU (a ruvC functional analog) on DNA repair [2].
  • Two further open reading frames of unknown function were identified, one on either side of the orf-33-ruvC operon [10].
  • The ruvC gene of Escherichia coli specifies a nuclease that resolves Holliday junction intermediates in genetic recombination (B. Connolly, C.A. Parsons, F.E. Benson, H.J. Dunderdale, G.J. Sharples, R.G. Lloyd, and S.C. West, Proc. Natl. Acad, Sci. USA 88:6063-6067, 1991) [10].

Other interactions of ruvC


Analytical, diagnostic and therapeutic context of ruvC


  1. Recombination-promoting activity of the bacteriophage lambda Rap protein in Escherichia coli K-12. Poteete, A.R., Fenton, A.C., Wang, H.R. J. Bacteriol. (2002) [Pubmed]
  2. The RuvAB branch migration translocase and RecU Holliday junction resolvase are required for double-stranded DNA break repair in Bacillus subtilis. Sanchez, H., Kidane, D., Reed, P., Curtis, F.A., Cozar, M.C., Graumann, P.L., Sharples, G.J., Alonso, J.C. Genetics (2005) [Pubmed]
  3. Genetic recombination in E. coli: RuvC protein cleaves Holliday junctions at resolution hotspots in vitro. Shah, R., Bennett, R.J., West, S.C. Cell (1994) [Pubmed]
  4. Partial suppression of the fission yeast rqh1(-) phenotype by expression of a bacterial Holliday junction resolvase. Doe, C.L., Dixon, J., Osman, F., Whitby, M.C. EMBO J. (2000) [Pubmed]
  5. RuvABC Is Required to Resolve Holliday Junctions That Accumulate following Replication on Damaged Templates in Escherichia coli. Donaldson, J.R., Courcelle, C.T., Courcelle, J. J. Biol. Chem. (2006) [Pubmed]
  6. Analysis of substrate specificity of the RuvC holliday junction resolvase with synthetic Holliday junctions. Shida, T., Iwasaki, H., Saito, A., Kyogoku, Y., Shinagawa, H. J. Biol. Chem. (1996) [Pubmed]
  7. Cells defective for replication restart undergo replication fork reversal. Grompone, G., Ehrlich, D., Michel, B. EMBO Rep. (2004) [Pubmed]
  8. Holliday junction resolvases encoded by homologous rusA genes in Escherichia coli K-12 and phage 82. Mahdi, A.A., Sharples, G.J., Mandal, T.N., Lloyd, R.G. J. Mol. Biol. (1996) [Pubmed]
  9. Molecular mechanisms of Holliday junction processing in Escherichia coli. Shinagawa, H., Iwasaki, H. Adv. Biophys. (1995) [Pubmed]
  10. Resolution of Holliday junctions in Escherichia coli: identification of the ruvC gene product as a 19-kilodalton protein. Sharples, G.J., Lloyd, R.G. J. Bacteriol. (1991) [Pubmed]
  11. Tandem repeat recombination induced by replication fork defects in Escherichia coli requires a novel factor, RadC. Saveson, C.J., Lovett, S.T. Genetics (1999) [Pubmed]
  12. Biological roles of the Escherichia coli RuvA, RuvB and RuvC proteins revealed. West, S.C., Connolly, B. Mol. Microbiol. (1992) [Pubmed]
  13. Crystallization of RusA Holliday junction resolvase from Escherichia coli. Muranova, T.A., Sedelnikova, S.E., Leonard, P.M., Pasquo, A., Bolt, E.L., Lloyd, R.G., Rafferty, J.B. Acta Crystallogr. D Biol. Crystallogr. (2003) [Pubmed]
WikiGenes - Universities