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Gene Review:

zwf - glucose-6-phosphate 1-dehydrogenase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1853, JW1841

Vinopal, R.T. et al., Porco, A. et al., Yoshida, Y. et al., Rowley, D.L. et al., Conway, T. et al.

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Disease relevance of zwf

Locations of the zwf, edd, and eda genes on the Escherichia coli physical map [1].

High impact information on zwf

The 5' ends of zwf mRNA isolated from cells growing in glucose and acetate minimal media were mapped [2].
However, they might be preferred for certain physiological studies, and we have prepared for this a new double mutant, strain DF214, with a Mu insertion in pgi and a deletion in zwf (flucose 6-phosphate dehydrogenase) [3].
The zwf gene encoding glucose 6-phosphate dehydrogenase, which is another enzyme consisting of pentose-phosphate pathway, sided at 3.8-kb upstream from the gnd gene [4].
In order to advance in this respect, the phage lambda placMu53 was used to select operon gnt::lacZ fusion in a E. coli strain delta (edd-zwf), delta (gnd-his), delta lac [5].

References

Locations of the zwf, edd, and eda genes on the Escherichia coli physical map. Conway, T., Yi, K.C., Egan, S.E., Wolf, R.E., Rowley, D.L. J. Bacteriol. (1991) [Pubmed]
Molecular characterization of the Escherichia coli K-12 zwf gene encoding glucose 6-phosphate dehydrogenase. Rowley, D.L., Wolf, R.E. J. Bacteriol. (1991) [Pubmed]
New phosphoglucose isomerase mutants of Escherichia coli. Vinopal, R.T., Hillman, J.D., Schulman, H., Reznikoff, W.S., Fraenkel, D.G. J. Bacteriol. (1975) [Pubmed]
The gnd gene encoding a novel 6-phosphogluconate dehydrogenase and its adjacent region of Actinobacillus actinomycetemcomitans chromosomal DNA. Yoshida, Y., Nakano, Y., Yamashita, Y., Koga, T. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
Selection of lacZ operon fusions in genes of gluconate metabolism in E. coli. characterization of a gntT::lacZ fusion. Porco, A., Istúriz, T. Acta Cient. Venez. (1991) [Pubmed]

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