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Gene Review

gnd  -  6-phosphogluconate dehydrogenase,...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2024, JW2011
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Disease relevance of gnd


High impact information on gnd

  • Enzymes from the pentose phosphate pathway (PPP) are potential drug targets for the development of new drugs against Trypanosoma brucei, the causative agent of African sleeping disease: for instance, the 6-phosphogluconate dehydrogenase is currently studied actively for such purposes [3].
  • Although the allele is strongly favored in chemostats in which the limiting nutrient is gluconate, the selective effects of gnd+ (862) are highly dependent on growth conditions [4].
  • In this study, we localized the gnd gene encoding gluconate-6-phosphate dehydrogenase at one end of the rfbEcO7 gene cluster and sequenced that end of the cluster [5].
  • Three open reading frames (ORF) encoding polypeptides of 275, 464, and 453 amino acids were identified upstream of gndEcO7, all transcribed toward the gnd gene [5].
  • Nucleotide sequences of the gnd genes from nine natural isolates of Escherichia coli: evidence of intragenic recombination as a contributing factor in the evolution of the polymorphic gnd locus [6].

Chemical compound and disease context of gnd


Biological context of gnd


Associations of gnd with chemical compounds

  • The zwf gene encoding glucose 6-phosphate dehydrogenase, which is another enzyme consisting of pentose-phosphate pathway, sided at 3.8-kb upstream from the gnd gene [2].

Other interactions of gnd


  1. Comparative nucleotide sequence analysis of growth-rate-regulated gnd alleles from natural isolates of Escherichia coli and from Salmonella typhimurium LT-2. Barcak, G.J., Wolf, R.E. J. Bacteriol. (1988) [Pubmed]
  2. The gnd gene encoding a novel 6-phosphogluconate dehydrogenase and its adjacent region of Actinobacillus actinomycetemcomitans chromosomal DNA. Yoshida, Y., Nakano, Y., Yamashita, Y., Koga, T. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  3. Three Dimensional Structure and Implications for the Catalytic Mechanism of 6-Phosphogluconolactonase from Trypanosoma brucei. Delarue, M., Duclert-Savatier, N., Miclet, E., Haouz, A., Giganti, D., Ouazzani, J., Lopez, P., Nilges, M., Stoven, V. J. Mol. Biol. (2007) [Pubmed]
  4. Fitness effects of a deletion mutation increasing transcription of the 6-phosphogluconate dehydrogenase gene in Escherichia coli. Miller, R.D., Dykhuizen, D.E., Hartl, D.L. Mol. Biol. Evol. (1988) [Pubmed]
  5. Identification, expression, and DNA sequence of the GDP-mannose biosynthesis genes encoded by the O7 rfb gene cluster of strain VW187 (Escherichia coli O7:K1). Marolda, C.L., Valvano, M.A. J. Bacteriol. (1993) [Pubmed]
  6. Nucleotide sequences of the gnd genes from nine natural isolates of Escherichia coli: evidence of intragenic recombination as a contributing factor in the evolution of the polymorphic gnd locus. Bisercić, M., Feutrier, J.Y., Reeves, P.R. J. Bacteriol. (1991) [Pubmed]
  7. DNA sequence of the Escherichia coli gene, gnd, for 6-phosphogluconate dehydrogenase. Nasoff, M.S., Baker, H.V., Wolf, R.E. Gene (1984) [Pubmed]
  8. Metabolic engineering of pentose phosphate pathway in Ralstoniaeutropha for enhanced biosynthesis of poly-beta-hydroxybutyrate. Lee, J.N., Shin, H.D., Lee, Y.H. Biotechnol. Prog. (2003) [Pubmed]
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