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Gene Review

pabC  -  4-amino-4-deoxychorismate lyase component...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1082, JW1082
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Disease relevance of pabC


High impact information on pabC

  • Other members are D-alanine aminotransferase and 4-amino-4-deoxychorismate lyase [2].
  • The aminodeoxychorismate lyase gene, designated pabC, was mapped to 25 min on the E. coli chromosome and lies on a 7.5-kilobase pair EcoRI fragment [1].
  • These cDNAs were shown to encode functional enzymes by complementation of an E. coli pabC mutant, and by demonstrating that the partially purified recombinant proteins convert ADC to PABA [3].
  • The FRT cassette was excised with high frequencies (close to 100%) from the chromosome after conjugal transfer of a Flp recombinase-expressing plasmid; this sacB-containing plasmid was subsequently cured by sucrose counterselection, resulting in an unmarked P. aeruginosa delta pabC strain [4].
  • Here we report the nucleotide sequence of tmk, including the end portion of an upstream open reading frame (ORF 340) of unknown function that may be cotranscribed with the pabC gene [5].

Chemical compound and disease context of pabC


Biological context of pabC


Associations of pabC with chemical compounds


Other interactions of pabC

  • Sequence analysis, confirmed by insertional knockout and specific substrate feeding experiments, shows that the position occupied by pabC (encoding aminodeoxychorismate lyase) in other bacteria is occupied instead by pabB (encoding aminodeoxychorismate synthase component I) in X. albilineans [8].


  1. p-Aminobenzoate biosynthesis in Escherichia coli. Purification of aminodeoxychorismate lyase and cloning of pabC. Green, J.M., Nichols, B.P. J. Biol. Chem. (1991) [Pubmed]
  2. Structure and function of branched chain aminotransferases. Hutson, S. Prog. Nucleic Acid Res. Mol. Biol. (2001) [Pubmed]
  3. Folate synthesis in plants: the last step of the p-aminobenzoate branch is catalyzed by a plastidial aminodeoxychorismate lyase. Basset, G.J., Ravanel, S., Quinlivan, E.P., White, R., Giovannoni, J.J., Rébeillé, F., Nichols, B.P., Shinozaki, K., Seki, M., Gregory, J.F., Hanson, A.D. Plant J. (2004) [Pubmed]
  4. A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally-located DNA sequences: application for isolation of unmarked Pseudomonas aeruginosa mutants. Hoang, T.T., Karkhoff-Schweizer, R.R., Kutchma, A.J., Schweizer, H.P. Gene (1998) [Pubmed]
  5. Escherichia coli thymidylate kinase: molecular cloning, nucleotide sequence, and genetic organization of the corresponding tmk locus. Reynes, J.P., Tiraby, M., Baron, M., Drocourt, D., Tiraby, G. J. Bacteriol. (1996) [Pubmed]
  6. Characterization and sequence of Escherichia coli pabC, the gene encoding aminodeoxychorismate lyase, a pyridoxal phosphate-containing enzyme. Green, J.M., Merkel, W.K., Nichols, B.P. J. Bacteriol. (1992) [Pubmed]
  7. An apparent Bacillus subtilis folic acid biosynthetic operon containing pab, an amphibolic trpG gene, a third gene required for synthesis of para-aminobenzoic acid, and the dihydropteroate synthase gene. Slock, J., Stahly, D.P., Han, C.Y., Six, E.W., Crawford, I.P. J. Bacteriol. (1990) [Pubmed]
  8. Characterization of the acyl carrier protein gene and the fab gene locus in Xanthomonas albilineans. Huang, G., Zhang, L., Birch, R.G. FEMS Microbiol. Lett. (2000) [Pubmed]
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