The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

lysP  -  lysine transporter

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2149, JW2143, cadR
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of lysP


High impact information on lysP

  • The cadR gene was inferred to encode an AraC/XylS type of transcriptional regulator from its deduced amino acid sequence [4].
  • The cadA promoter was responsive to Cd(II), Pb(II), and Zn(II), while the cadR promoter was only induced by Cd(II) [2].
  • Transcription of lysP (encodes a lysine transporter) was also examined, since it is a negative regulator of cadBA expression in the absence of lysine. lysP expression was repressed by lysine but not influenced by pH [5].
  • Expression of cadA-lacZ in a strain carrying the cadC310 allele, however, was not affected by the plasmid-expressed lysP [6].
  • The lysP-phoA fusion was cloned and used as a probe to clone the wild-type lysP gene [7].

Biological context of lysP


Associations of lysP with chemical compounds

  • Three other mutants had mutations mapping in or near lysP (cadR), a gene encoding a lysine transport protein that has previously been shown to regulate cadA expression [6].
  • Mutational analysis indicated that cadA and cadR are fully responsible for cadmium resistance and partially for zinc resistance [2].

Analytical, diagnostic and therapeutic context of lysP


  1. Expression of the rocDEF operon involved in arginine catabolism in Bacillus subtilis. Gardan, R., Rapoport, G., Débarbouillé, M. J. Mol. Biol. (1995) [Pubmed]
  2. Chromosomal locus for cadmium resistance in Pseudomonas putida consisting of a cadmium-transporting ATPase and a MerR family response regulator. Lee, S.W., Glickmann, E., Cooksey, D.A. Appl. Environ. Microbiol. (2001) [Pubmed]
  3. Characterization of the arcD arginine:ornithine exchanger of Pseudomonas aeruginosa. Localization in the cytoplasmic membrane and a topological model. Bourdineaud, J.P., Heierli, D., Gamper, M., Verhoogt, H.J., Driessen, A.J., Konings, W.N., Lazdunski, C., Haas, D. J. Biol. Chem. (1993) [Pubmed]
  4. Novel 2,4-dichlorophenoxyacetic acid degradation genes from oligotrophic Bradyrhizobium sp. strain HW13 isolated from a pristine environment. Kitagawa, W., Takami, S., Miyauchi, K., Masai, E., Kamagata, Y., Tiedje, J.M., Fukuda, M. J. Bacteriol. (2002) [Pubmed]
  5. Kinetics of expression of the Escherichia coli cad operon as a function of pH and lysine. Neely, M.N., Olson, E.R. J. Bacteriol. (1996) [Pubmed]
  6. Roles of LysP and CadC in mediating the lysine requirement for acid induction of the Escherichia coli cad operon. Neely, M.N., Dell, C.L., Olson, E.R. J. Bacteriol. (1994) [Pubmed]
  7. The lysP gene encodes the lysine-specific permease. Steffes, C., Ellis, J., Wu, J., Rosen, B.P. J. Bacteriol. (1992) [Pubmed]
  8. Topological analysis of the lysine-specific permease of Escherichia coli. Ellis, J., Carlin, A., Steffes, C., Wu, J., Liu, J., Rosen, B.P. Microbiology (Reading, Engl.) (1995) [Pubmed]
WikiGenes - Universities