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Gene Review:

flhC - flagellar class II regulon transcriptional...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1892, JW1880, flaI

Patenge, N. et al., Farr, S.B. et al., Szmelcman, S. et al., Sourjik, V. et al.

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High impact information on flhC

Expression of the flbB/flaI operon, thought to encode sigma F, is decreased in apaH- mutants, and there appears to be a general decrease in expression of genes regulated by cAMP-binding protein and cAMP as well [1].
(iv) A mutant in a control gene )flaI), unable to synthesize flagella and cytoplasmic membrane proteins related to motility and chemotaxis, failed to give the peak [2].
Therefore, the flaI gene product is involved in the biosynthesis, transport or assembly of flagella in H. salinarum [3].
The ORFs of flaH, flaI and flaK contain sequences coding for nucleotide binding sites [3].
Furthermore, flaI contains a motif called the bacterial type II secretion protein E signature, indicating a functional relation to members of the bacterial pili type IV-type II secretion protein superfamily [3].

Other interactions of flhC

These were seen in wild-type cells and in a fliN mutant, but not in flhC or fliG mutants [4].

References

An apaH mutation causes AppppA to accumulate and affects motility and catabolite repression in Escherichia coli. Farr, S.B., Arnosti, D.N., Chamberlin, M.J., Ames, B.N. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
Change in membrane potential during bacterial chemotaxis. Szmelcman, S., Adler, J. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
The fla gene cluster is involved in the biogenesis of flagella in Halobacterium salinarum. Patenge, N., Berendes, A., Engelhardt, H., Schuster, S.C., Oesterhelt, D. Mol. Microbiol. (2001) [Pubmed]
Localization of components of the chemotaxis machinery of Escherichia coli using fluorescent protein fusions. Sourjik, V., Berg, H.C. Mol. Microbiol. (2000) [Pubmed]

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