Disease relevance of suhB

• Computer analyses, detailed elsewhere, revealed significant amino acid sequence homology between cysQ and suhB of E. coli and the gene for mammalian inositol monophosphatase [1].
• The Rhizobium leguminosarum bv. trifolii pssB gene product is an inositol monophosphatase that influences exopolysaccharide synthesis [2].

High impact information on suhB

• In contrast, the pET23a(+) recombinant plasmid with the wild-type E. coli suhB gene complemented the cold sensitivity of the chromosomal mutant suhB and restored the temperature-sensitive growth of the dnaB mutation in the double mutant strain CG1307 [3].
• Unexpected similarity in regulation between an archaeal inositol monophosphatase/fructose bisphosphatase and chloroplast fructose bisphosphatase [4].
• These mutant alleles of suhB cause cold-sensitive cell growth, indicating that the suhB gene is essential at low temperatures [5].
• The suhB gene is located at 55 min on the Escherichia coli chromosome and encodes a protein of 268 amino acids [5].
• The purified Rv2131c gene product showed inositol monophosphatase activity but with substrate specificity that was broader than those of several bacterial and eukaryotic inositol monophosphatases, and it also acted as fructose-1,6-bisphosphatase [6].

Chemical compound and disease context of suhB

• The suhB gene encodes a 29-kDa protein that possesses inositol monophosphate activity and its mutations suppress several temperature-sensitive mutations in Escherichia coli [7].
• Lithium-sensitive inositol monophosphatase from bovine brain was purified from brain and from a recombinant strain of Escherichia coli BL21-DE3 [8].

Biological context of suhB

• Autogenous control of the suhB gene expression of Escherichia coli [7].

Associations of suhB with chemical compounds

• Inositol monophosphatase can be modified at two sites by pyrene maleimide [9].

Other interactions of suhB

• Lethal double-stranded RNA processing activity of ribonuclease III in the absence of suhB protein of Escherichia coli [10].

References