Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

tdcA - tdc operon transcriptional activator

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3107, JW3089

Torres, A.G. et al., Hagewood, B.T. et al.

Torres, Jeter, Langley, Matthysse,

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Disease relevance of tdcA

The efficient expression of the tdc operon of Escherichia coli requires the products of two regulatory genes, tdcR and tdcA [1].

High impact information on tdcA

Only the absence of the ompA gene had a significant effect on binding, and the plant-bacterium interaction was markedly reduced in a tdcA ompA double mutant [2].
Interestingly, multicopy tdcA+ plasmids introduced into tdcR mutant strains completely restored tdc expression [1].

Anatomical context of tdcA

In contrast, the E. coli O157:H7 ompA and tdcA ompA mutant strains were only slightly affected in adhesion to Caco-2 cells and during biofilm formation [2].

References

Functional analysis of the tdcABC promoter of Escherichia coli: roles of TdcA and TdcR. Hagewood, B.T., Ganduri, Y.L., Datta, P. J. Bacteriol. (1994) [Pubmed]
Differential binding of Escherichia coli O157:H7 to alfalfa, human epithelial cells, and plastic is mediated by a variety of surface structures. Torres, A.G., Jeter, C., Langley, W., Matthysse, A.G. Appl. Environ. Microbiol. (2005) [Pubmed]

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