Disease relevance of arsB

• Average sequence divergence within arsB for six creek enteric bacteria was 20% compared to that of the E. coli R773 ars operon [1].

High impact information on arsB

• In addition, these three mutant alleles conferred arsenite sensitivity in cells carrying the wild type arsB gene [2].
• Homology of Escherichia coli R773 arsA, arsB, and arsC genes in arsenic-resistant bacteria isolated from raw sewage and arsenic-enriched creek waters [1].
• The arsRC genes were co-transcribed with ORF1, and arsB with ORF5 in both At. caldus and Escherichia coli, although deletion of ORFs 1 and 5 did not appear to affect resistance to arsenate or arsenite in E. coli [3].
• Southern hybridization analysis showed that At. caldus and other gram-negative acidophiles carry an Escherichia coli arsB homologue on the chromosome [4].
• DNA sequencing revealed three open reading frames homologous to the arsR, arsB, and arsC open reading frames of plasmid-based arsenic resistance operons isolated from both E. coli and staphylococcal species [5].

Biological context of arsB

• This chromosomal operon was cloned, sequenced, and found to consist of three cistrons which we named arsR, arsB, and arsC because of their strong homology to plasmid-borne ars operons [6].
• Nucleotide sequencing revealed the presence of three open reading frames homologous to the arsR, arsB and arsC genes of arsenic resistance [7].

Analytical, diagnostic and therapeutic context of arsB

• Only 1 of 11 pseudomonads screened by PCR was positive for arsB [1].

References