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Gene Review

ilvC  -  ketol-acid reductoisomerase, NAD(P)-binding

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3766, JW3747
 
 
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Disease relevance of ilvC

 

High impact information on ilvC

 

Biological context of ilvC

  • A model is presented in which the ilvY-encoded activator binds to an operator site in the overlapping promoter region and reciprocally regulates the transcription of the ilvY and ilvC genes [1].
 

Other interactions of ilvC

  • The ilvY gene is transcribed in a direction opposite to the ilvC and ilvGMEDA genes [1].
 

Analytical, diagnostic and therapeutic context of ilvC

References

  1. Nucleotide sequence and in vivo expression of the ilvY and ilvC genes in Escherichia coli K12. Transcription from divergent overlapping promoters. Wek, R.C., Hatfield, G.W. J. Biol. Chem. (1986) [Pubmed]
  2. Cloning, organization and functional analysis of ilvA, ilvB and ilvC genes from Corynebacterium glutamicum. Cordes, C., Möckel, B., Eggeling, L., Sahm, H. Gene (1992) [Pubmed]
  3. Oxalyl hydroxamates as reaction-intermediate analogues for ketol-acid reductoisomerase. Aulabaugh, A., Schloss, J.V. Biochemistry (1990) [Pubmed]
  4. Facile crystallization of Escherichia coli ketol-acid reductoisomerase. McCourt, J.A., Tyagi, R., Guddat, L.W., Biou, V., Duggleby, R.G. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
 
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