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Gene Review

metJ  -  transcriptional repressor, S...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3930, JW3909
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Disease relevance of metJ


High impact information on metJ

  • The subunit size and the amino acid composition are the same as those predicted from the DNA sequence of the metJ gene [1].
  • Bacterial strains carrying this plasmid produce elevated levels of the metJ gene product, presumably because of the high number of gene copies in the cell [1].
  • Structure and autoregulation of the metJ regulatory gene in Escherichia coli [2].
  • Analysis of the sequence downstream from the metJ gene has revealed inverted repeats homologous to several intercistronic regions, also reported to occur between operons [2].
  • Three of the mutations in the metK structural gene were then introduced into metJ and thrBC double-mutant strains; one of the resultant strains was found to accumulate 0.13 g/liter Met [3].

Biological context of metJ

  • Evidence was provided for autoregulation by repression of the metJ gene [2].
  • In a simplified system that measures the formation of the first dipeptide of the gene product (fMet-Ala for the metJ gene), MetJ protein and AdoMet partially repress (approximately 40-60%) metJ gene expression [4].

Associations of metJ with chemical compounds

  • Expression of methionine regulon elements was controlled by the metJ protein gpMetJ [5].

Analytical, diagnostic and therapeutic context of metJ


  1. Isolation and characterization of the product of the methionine-regulatory gene metJ of Escherichia coli K-12. Smith, A.A., Greene, R.C., Kirby, T.W., Hindenach, B.R. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  2. Structure and autoregulation of the metJ regulatory gene in Escherichia coli. Saint-Girons, I., Duchange, N., Cohen, G.N., Zakin, M.M. J. Biol. Chem. (1984) [Pubmed]
  3. Effects of deregulation of methionine biosynthesis on methionine excretion in Escherichia coli. Usuda, Y., Kurahashi, O. Appl. Environ. Microbiol. (2005) [Pubmed]
  4. Regulation of methionine synthesis in Escherichia coli: effect of metJ gene product and S-adenosylmethionine on the in vitro expression of the metB, metL and metJ genes. Shoeman, R., Coleman, T., Redfield, B., Greene, R.C., Smith, A.A., Saint-Girons, I., Brot, N., Weissbach, H. Biochem. Biophys. Res. Commun. (1985) [Pubmed]
  5. Control of metF gene expression in maxicell preparations of Escherichia coli K-12: reversible action of the metJ protein and effect of vitamin B12. Emmett, M.R., Johnson, J.R. J. Bacteriol. (1986) [Pubmed]
  6. Transcript analysis reveals an extended regulon and the importance of protein-protein co-operativity for the Escherichia coli methionine repressor. Marincs, F., Manfield, I.W., Stead, J.A., McDowall, K.J., Stockley, P.G. Biochem. J. (2006) [Pubmed]
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